Ion-Based Proteome-Integrated Solubility Alteration Assays for Systemwide Profiling of Protein–Molecule Interactions
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DOI: 10.1021/acs.analchem.2c00391
Abstract: Unbiased drug target engagement deconvolution and mechanism of action elucidation are major challenges in drug development. Modification-free target engagement methods, such as thermal proteome profiling, have gained increasing popularity in the last several years. However,… read more here.
Keywords: solubility; proteome integrated; integrated solubility; solubility alteration ... See more keywords