The integrated stress response in the induction of mutant KRAS lung carcinogenesis: Mechanistic insights and therapeutic implications
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200026
Abstract: The integrated stress response (ISR) is a key determinant of tumorigenesis in response to oncogenic forms of stress like genotoxic, proteotoxic and metabolic stress. ISR relies on the phosphorylation of the translation initiation factor eIF2… read more here.
Keywords: induction mutant; stress response; lung; response induction ... See more keywords
Harnessing the Integrated Stress Response to Counteract Metabolic Disease
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30152
Abstract: Over a decade ago, fibroblast growth factor 21 (FGF21) was identified as a novel regulator of metabolism (1). Since that time, accumulating data have substantiated the therapeutic potential of this hormone in counteracting metabolic disease.… read more here.
Keywords: metabolic disease; integrated stress; disease; stress response ... See more keywords
An Overview of Methods for Detecting eIF2α Phosphorylation and the Integrated Stress Response.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1975-9_1
Abstract: Phosphorylation of the translation initiation factor eIF2α is an adaptive signaling event that is essential for cell and organismal survival from yeast to humans. It is central to the integrated stress response (ISR) that maintains… read more here.
Keywords: stress response; eif2 phosphorylation; phosphorylation; overview methods ... See more keywords
Carbon monoxide induces the assembly of stress granule through the integrated stress response.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.017
Abstract: Stress granules (SGs) are membraneless and phase-dense organelles that form transiently in response to a variety of harmful stimuli, including oxidative, heat, osmotic, ultraviolet light and chemotoxic stresses, and thus providing protective effects, allowing survivals.… read more here.
Keywords: isr; response; integrated stress; induces assembly ... See more keywords
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.08.009
Abstract: FGF21 is a multifunctional metabolic and stress hormone which is normally expressed in liver but cellular stress, e.g. mitochondrial or endoplasmic reticulum (ER) stress, can induce its expression and subsequent secretion from several mammalian tissues.… read more here.
Keywords: longevity; metabolic stress; integrated stress; stress ... See more keywords
The integrated stress response system in cardiovascular disease.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.02.008
Abstract: The integrated stress response system represents an ancillary, extremely conserved signalling pathway present in virtually all eukaryotic cells, which plays an important part in the pathophysiology of several disorders such as cancer and neurodegeneration. However,… read more here.
Keywords: system cardiovascular; response system; system; integrated stress ... See more keywords
Integrated stress response activation by sleep fragmentation during late gestation in mice leads to emergence of adverse metabolic phenotype in offspring.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2017.01.026
Abstract: BACKGROUND Late gestational sleep fragmentation (SF) is highly prevalent particularly in obese women, and induces metabolic dysfunction in adult offspring mice. SF induces activation of the integrated stress response (ISR), which might be involved in… read more here.
Keywords: gestation; sleep fragmentation; integrated stress; mice ... See more keywords
Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.12.006
Abstract: Biological phase transitions form membrane-less organelles that generate distinct cellular environments. How molecules are partitioned between these compartments and the surrounding cellular space and the functional consequence of this localization is not well understood. Here,… read more here.
Keywords: localization; integrated stress; single molecule; stress response ... See more keywords
Folding the Mitochondrial UPR into the Integrated Stress Response.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2020.03.001
Abstract: Eukaryotic cells must accurately monitor the integrity of the mitochondrial network to overcome environmental insults and respond to physiological cues. The mitochondrial unfolded protein response (UPRmt) is a mitochondrial-to-nuclear signaling pathway that maintains mitochondrial proteostasis,… read more here.
Keywords: response; mitochondrial upr; integrated stress; stress response ... See more keywords
Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0491-z
Abstract: Imipridones constitute a novel class of antitumor agents. Here, we report that a second-generation imipridone, ONC212, possesses highly increased antitumor activity compared to the first-generation compound ONC201. In vitro studies using human acute myeloid leukemia… read more here.
Keywords: imipridone onc212; gpr132; integrated stress; stress response ... See more keywords
Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26164-4
Abstract: Viral infection triggers activation of the integrated stress response (ISR). In response to viral double-stranded RNA (dsRNA), RNA-activated protein kinase (PKR) phosphorylates the translation initiation factor eIF2, converting it from a translation initiator into a… read more here.
Keywords: response; stress response; eif2 binding; viral evasion ... See more keywords