Integrated testing strategies can be optimal for chemical risk classification.
Sign Up to like & getrecommendations! Published in 2017 at "Mathematical biosciences"
DOI: 10.1016/j.mbs.2017.05.005
Abstract: There is an urgent need to refine strategies for testing the safety of chemical compounds. This need arises both from the financial and ethical costs of animal tests, but also from the opportunities presented by… read more here.
Keywords: strategies optimal; chemical risk; testing strategies; integrated testing ... See more keywords
Skin Sensitization: Challenging the Conventional Thinking—A Case Against 2 Out of 3 as Integrated Testing Strategy
Sign Up to like & getrecommendations! Published in 2017 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfx115
Abstract: Recent years have seen a surge in development of alternative methods for assessment of skin sensitizers. This has been in order to meet the regulatory and industrial demand for accurate safety assessment without the use… read more here.
Keywords: conventional thinking; integrated testing; skin sensitization; thinking case ... See more keywords
SkinSensPred as a Promising in Silico Tool for Integrated Testing Strategy on Skin Sensitization
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph191912856
Abstract: Skin sensitization is an important regulatory endpoint associated with allergic contact dermatitis. Recently, several adverse outcome pathway (AOP)-based alternative methods were developed to replace animal testing for evaluating skin sensitizers. The AOP-based assays were further… read more here.
Keywords: testing strategy; sensitization; integrated testing; skin sensitization ... See more keywords