Integrating comparative modeling and accelerated simulations reveals conformational and energetic basis of actomyosin force generation
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DOI: 10.1073/pnas.2215836120
Abstract: Significance Interactions between myosin and actin are essential in producing various cellular forces. Targeting cardiac myosin, several small molecules have been developed to treat cardiomyopathy. A clear mechanistic picture of the allosteric control in the… read more here.
Keywords: modeling accelerated; comparative modeling; actomyosin; integrating comparative ... See more keywords