Integration of 3D genome topology and local chromatin features uncovers enhancers underlying craniofacial-specific cartilage defects
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DOI: 10.1126/sciadv.abo3648
Abstract: Aberrations in tissue-specific enhancers underlie many developmental defects. Disrupting a noncoding region distal from the human SOX9 gene causes the Pierre Robin sequence (PRS) characterized by the undersized lower jaw. Such a craniofacial-specific defect has… read more here.
Keywords: topology; cartilage; craniofacial specific; genome topology ... See more keywords