Genome-wide integration site detection using Cas9 enriched amplification-free long-range sequencing
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1152
Abstract: Abstract The gene and cell therapy fields are advancing rapidly, with a potential to treat and cure a wide range of diseases, and lentivirus-based gene transfer agents are the vector of choice for many investigators.… read more here.
Keywords: integration; range; amplification free; integration site ... See more keywords
Target search by an imported conjugative DNA element for a unique integration site along a bacterial chromosome during horizontal gene transfer
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad068
Abstract: Abstract Integrative and conjugative elements (ICEs) are mobile genetic elements that can transfer by conjugation to recipient cells. Some ICEs integrate into a unique site in the genome of their hosts. We studied quantitatively the… read more here.
Keywords: dna; integration site; unique integration; search ... See more keywords
Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.00007-22
Abstract: A longstanding question exists on the impact of the HIV-1 integration site on viral gene expression. This unsolved question has significant implications for the search toward an HIV-1 cure, as eradication strategies set up to… read more here.
Keywords: integration site; hiv; provirus; integration ... See more keywords
Identification of antibody against wingless‑type MMTV integration site family member 7B as a biliary cancer tumor marker.
Sign Up to like & getrecommendations! Published in 2022 at "Oncology reports"
DOI: 10.3892/or.2022.8471
Abstract: Biliary cancer has a poor prognosis due to a lack of specific biomarkers and difficulty in diagnosis. The present study aimed to identify serum tumor markers for the diagnosis of biliary cancer via serological identification… read more here.
Keywords: integration site; mmtv integration; biliary cancer; type mmtv ... See more keywords