Integrative analyses for the identification of idiopathic pulmonary fibrosis-associated genes and shared loci with other diseases
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DOI: 10.1136/thorax-2021-217703
Abstract: Background Although genome-wide association studies (GWAS) have identified many genomic regions associated with idiopathic pulmonary fibrosis (IPF), the causal genes and functions remain largely unknown. Many single-cell expression data have become available for IPF, and… read more here.
Keywords: candidate genes; ipf; idiopathic pulmonary; pulmonary fibrosis ... See more keywords
Integrative Analyses Reveal the Anticancer Mechanisms and Sensitivity Markers of the Next-Generation Hypomethylating Agent NTX-301
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DOI: 10.3390/cancers15061737
Abstract: Simple Summary We thoroughly investigated the experimental and preclinical efficacy of the novel hypomethylating agent (HMA) NTX-301 through comparative analyses with conventional HMAs. By performing multiomics data analyses, we demonstrated the mechanisms of action underlying… read more here.
Keywords: sensitivity; ntx 301; hypomethylating agent; efficacy ... See more keywords
Integrative Analyses of Transcriptomes to Explore Common Molecular Effects of Antipsychotic Drugs
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DOI: 10.3390/ijms23147508
Abstract: There is little understanding of the underlying molecular mechanism(s) involved in the clinical efficacy of antipsychotics for schizophrenia. This study integrated schizophrenia-associated transcriptional perturbations with antipsychotic-induced gene expression profiles to detect potentially relevant therapeutic targets… read more here.
Keywords: antipsychotic drugs; explore common; analyses transcriptomes; integrative analyses ... See more keywords