Integrative analysis of gut microbiome and host transcriptomes reveals associations between treatment outcomes and immunotherapy-induced colitis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13062
Abstract: Immune checkpoint inhibitors (ICIs) are widely used to treat various malignancies. Although the gut microbiome is known to influence the efficacy of ICIs on epithelial tumors, the functional interactions between gut taxa and colonic mucosa remain… read more here.
Keywords: integrative analysis; host transcriptomes; gut microbiome; microbiome ... See more keywords
Integrative analysis of mRNA and microRNA expression profiles in laryngeal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27612
Abstract: Larynx cancer is a therapeutically challenging disease. Rapidly evolving experimentally validated data have significantly improved our understanding of the complex role of numerous RNA, DNA, and proteins that play a role in the development and… read more here.
Keywords: integrative analysis; expression; role; larynx cancer ... See more keywords
Promoting similarity of model sparsity structures in integrative analysis of cancer genetic data.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7138
Abstract: In profiling studies, the analysis of a single dataset often leads to unsatisfactory results because of the small sample size. Multi-dataset analysis utilizes information of multiple independent datasets and outperforms single-dataset analysis. Among the available… read more here.
Keywords: integrative analysis; similarity model; similarity; analysis ... See more keywords
Integrative analysis revealed potential causal genetic and epigenetic factors for multiple sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurology"
DOI: 10.1007/s00415-019-09476-w
Abstract: ObjectiveMany genomic loci have been identified for multiple sclerosis (MS) by genome-wide association studies (GWAS). Discrimination of the most functionally relevant genes in these loci remains challenging. The aim of this study was to highlight… read more here.
Keywords: integrative analysis; micb granzyme; causal; multiple sclerosis ... See more keywords
Integrative analysis of transcriptomics and metabolomics reveals the hepatotoxic mechanism of thiamethoxam on male Coturnix japonica.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.118460
Abstract: Thiamethoxam (TMX), a representative neonicotinoids, is widely used for seed coating. The consumption of TMX-coated seeds posed threat to birds during crop sowing. The hepatotoxicity of TMX has been reported in mammals, however, no clear… read more here.
Keywords: integrative analysis; tmx; analysis; analysis transcriptomics ... See more keywords
Integrative analysis of the metabolome and transcriptome provides insights into the mechanisms of flavonoid biosynthesis in blackberry.
Sign Up to like & getrecommendations! Published in 2022 at "Food research international"
DOI: 10.1016/j.foodres.2022.110948
Abstract: Blackberry fruit is rich in anthocyanins, showing incomparable nutritional and health value. Anthocyanins are flavonoids that are downstream products of the flavonoid biosynthesis pathway. They are important secondary metabolites with antioxidant and anticancer functions. Therefore,… read more here.
Keywords: biosynthesis; flavonoid biosynthesis; integrative analysis; blackberry ... See more keywords
GW28-e0586 Study on the pathological mechanisms of heart failure by integrative analysis of transcriptomics and proteomics
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.07.212
Abstract: Heart failure (HF) is the leading cause of morbidity and mortality worldwide. Elucidating the mechanisms of HF remains a significant challenge due to multidimensional alterations at molecular, cellular, tissue, and organ levels. Integrative analysis of… read more here.
Keywords: integrative analysis; gw28 e0586; heart failure;
Integrative analysis of the Lake Simcoe watershed (Ontario, Canada) as a socio-ecological system.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of environmental management"
DOI: 10.1016/j.jenvman.2016.11.073
Abstract: Striving for long-term sustainability in catchments dominated by human activities requires development of interdisciplinary research methods to account for the interplay between environmental concerns and socio-economic pressures. In this study, we present an integrative analysis… read more here.
Keywords: lake simcoe; simcoe watershed; integrative analysis;
Integrative Analysis of Periostin in Primary and Advanced Prostate Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Translational Oncology"
DOI: 10.1016/j.tranon.2020.100789
Abstract: Periostin (POSTN) is an extracellular matrix protein associated with tumor progression and shorter survival in prostate cancer (PCa). Here, we performed an integrative analysis of POSTN’s role in patients with PCa. Clinical and POSTN data… read more here.
Keywords: integrative analysis; analysis; postn; prostate cancer ... See more keywords
Integrative Analysis of Metabolomic and Transcriptomic Data Reveals Metabolic Alterations in Glioma Patients.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.0c00697
Abstract: Glioma is a malignant brain tumor. There is growing evidence that its progression involves altered metabolism. This study's objective was to understand how those metabolic perturbations were manifested in plasma and urine. Metabolic signatures in… read more here.
Keywords: glioma patients; integrative analysis; metabolomic transcriptomic; glioma ... See more keywords
Integrative analysis of desert dust size and abundance suggests less dust climate cooling.
Sign Up to like & getrecommendations! Published in 2017 at "Nature geoscience"
DOI: 10.1038/ngeo2912
Abstract: Desert dust aerosols affect Earth's global energy balance through interactions with radiation1,2, clouds3,4, and ecosystems5. But the magnitudes of these effects are so uncertain that it remains unclear whether atmospheric dust has a net warming… read more here.
Keywords: integrative analysis; dust; desert dust; climate ... See more keywords