Integrative computational approaches identify haptoglobin inhibitors to modulate erythrocyte sedimentation rate in trauma-linked inflammatory and haematological malignancies
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2025.1611972
Abstract: Elevated levels of haptoglobin are commonly observed in conditions characterised by an increased erythrocyte sedimentation rate which are acute-phase reactants. These conditions include infection, trauma, inflammation, hepatitis, amyloidosis, collagen diseases, lymphoma, leukaemia, as well as… read more here.
Keywords: erythrocyte sedimentation; sedimentation rate; computational approaches; integrative computational ... See more keywords
Editorial: Integrative Computational Systems Biology Approaches in Immunology and Medicine
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DOI: 10.3389/fmicb.2018.03338
Abstract: Editorial on the Research Topic "Integrative Computational Systems Biology Approaches in Immunology and Medicine" read more here.
Keywords: integrative computational; medicine; computational systems; biology ... See more keywords
Integrative Computational Modeling of Distinct Binding Mechanisms for Broadly Neutralizing Antibodies Targeting SARS-CoV-2 Spike Omicron Variants: Balance of Evolutionary and Dynamic Adaptability in Shaping Molecular Determinants of Immune Escape
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DOI: 10.3390/v17060741
Abstract: In this study, we conducted a comprehensive analysis of the interactions between the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein and four neutralizing antibodies—S309, S304, CYFN1006, and VIR-7229. Using integrative computational modeling that combined… read more here.
Keywords: sars cov; computational modeling; cov spike; integrative computational ... See more keywords