Integrative functional genomics identifies regulatory genetic variant modulating RAB31 expression and altering susceptibility to breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22902
Abstract: Despite the successes of genome‐wide association study (GWAS) in identifying breast cancer (BC) risk‐associated variants, only a small fraction of the heritability can be explained. The greatest challenge in the post‐GWAS is to identify causal… read more here.
Keywords: regulatory genetic; susceptibility; integrative functional; breast cancer ... See more keywords
Integrative Functional Genomics for Systems Genetics in GeneWeaver.org.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6427-7_6
Abstract: The abundance of existing functional genomics studies permits an integrative approach to interpreting and resolving the results of diverse systems genetics studies. However, a major challenge lies in assembling and harmonizing heterogeneous data sets across… read more here.
Keywords: geneweaver org; integrative functional; genetics; functional genomics ... See more keywords
Integrative Functional Genomic Analysis in Multiplex Autism Families from Kazakhstan
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/1509994
Abstract: The study of extended pedigrees containing autism spectrum disorder- (ASD-) related broader autism phenotypes (BAP) offers a promising approach to the search for ASD candidate variants. Here, a total of 650,000 genetic markers were tested… read more here.
Keywords: multiplex autism; autism; analysis multiplex; genomic analysis ... See more keywords
An integrative functional genomics approach reveals EGLN1 as a novel therapeutic target in KRAS mutated lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer"
DOI: 10.1186/s12943-021-01357-z
Abstract: Main text Despite extensive research and the recent introduction of innovative therapeutics, lung cancer remains the first cause of cancer-related death, with a 5 year survival of only 17% [1]. In lung adenocarcinoma (AD), the… read more here.
Keywords: lung adenocarcinoma; kras mutated; mutated lung; integrative functional ... See more keywords