Multiple testing approaches for hypotheses in integrative genomics
Sign Up to like & getrecommendations! Published in 2019 at "Wiley Interdisciplinary Reviews: Computational Statistics"
DOI: 10.1002/wics.1493
Abstract: With the explosion in available technologies for measuring many biological phenomena on a large scale, there have been concerted efforts in a variety of biological and medical settings to perform systems biology analyses. A crucial… read more here.
Keywords: hypotheses integrative; integrative genomics; testing approaches; approaches hypotheses ... See more keywords
Precision oncology in the age of integrative genomics
Sign Up to like & getrecommendations! Published in 2018 at "Nature Biotechnology"
DOI: 10.1038/nbt.4017
Abstract: Precision oncology applies genomic and other molecular analyses of tumor biopsies to improve the diagnosis and treatment of cancers. In addition to identifying therapeutic options, precision oncology tracks the response of a tumor to an… read more here.
Keywords: oncology age; integrative genomics; precision oncology; oncology ... See more keywords
Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac296
Abstract: Abstract Prenatal exposure to the anti-seizure medication sodium valproate (VPA) is associated with an increased risk of adverse postnatal neurodevelopmental outcomes, including lowered intellectual ability, autism spectrum disorder and attention-deficit hyperactivity disorder. In this study,… read more here.
Keywords: valproate; vpa; neurodevelopmental disability; gene expression ... See more keywords
Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddab125
Abstract: Abstract The systematic identification of host genetic risk factors is essential for the understanding and treatment of coronavirus disease 2019 (COVID-19). By performing a meta-analysis of two independent genome-wide association summary datasets (N = 680 128), a novel… read more here.
Keywords: ifnar2 il10rb; genomics analysis; integrative genomics; covid ... See more keywords
Integrative genomics analysis highlights functionally relevant genes for equine behaviour.
Sign Up to like & getrecommendations! Published in 2023 at "Animal genetics"
DOI: 10.1111/age.13320
Abstract: Behavioural plasticity enables horses entering an exercise training programme to adapt with reduced stress. We characterised SNPs associated with behaviour in yearling Thoroughbred horses using genomics analyses for two phenotypes: (1) handler-assessed coping with early… read more here.
Keywords: genomics analysis; functionally relevant; relevant genes; analysis highlights ... See more keywords
The landscape of early carcinogenesis revealed through the lens of integrative genomics, epigenomics, and transcriptomics.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2019.06.07
Abstract: The hallmarks of established cancers have been meticulously catalogued over decades, almost entirely through the study of advanced disease (1). By contrast, the molecular features of early pre-neoplastic lesions including the occult alterations that presage… read more here.
Keywords: landscape early; early carcinogenesis; lens integrative; integrative genomics ... See more keywords
Application of integrative genomics and systems biology to conventional and in vitro reproductive traits in cattle
Sign Up to like & getrecommendations! Published in 2017 at "Animal reproduction"
DOI: 10.21451/1984-3143-ar993
Abstract: Assisted reproductive technologies (ARTs) have a strong impact on breeding especially when coupled with genomic selection (GS). The routine implementation of in vitro production (IVP) and GS of embryos before embryo transfer (ET) in breeding… read more here.
Keywords: integrative genomics; genomics systems; biology conventional; biology ... See more keywords
Integrative Genomics Analysis Unravels Tissue-Specific Pathways, Networks, and Key Regulators of Blood Pressure Regulation
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2019.00021
Abstract: Blood pressure (BP) is a highly heritable trait and a major cardiovascular disease risk factor. Genome wide association studies (GWAS) have implicated a number of susceptibility loci for systolic (SBP) and diastolic (DBP) blood pressure.… read more here.
Keywords: tissue specific; integrative genomics; blood pressure; sbp ... See more keywords