An Integrative Proteome-Based Pharmacologic Characterization and Therapeutic Strategy Exploration of SAHA in Solid Malignancies.
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DOI: 10.1021/acs.jproteome.1c00791
Abstract: Targeting histone epigenetic modification is an important strategy for anticancer therapy. Histone deacetylase inhibitors (HDACis) have been clinically approved in the treatment of diverse hematological cancers, but mechanisms of drug resistance and poor therapeutic efficacy… read more here.
Keywords: saha; integrative proteome; strategy; drug ... See more keywords