LAUSR

Integrative Single‐Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental Dynamics

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2 Published in 2023 at "Advanced Science"

DOI: 10.1002/advs.202206623

Abstract: The underlying mechanisms that determine gene expression and chromatin accessibility in retinogenesis are poorly understood. Herein, single‐cell RNA sequencing and single‐cell assay for transposase‐accessible chromatin sequencing are performed on human embryonic eye samples obtained 9–26… read more here.

Keywords: developmental dynamics; cell; integrative single; retina ... See more keywords

Integrative Single-Plaque Analysis Reveals Signature Aβ and Lipid Profiles in the Alzheimer’s Brain

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0 Published in 2024 at "Analytical Chemistry"

DOI: 10.1021/acs.analchem.3c05557

Abstract: Cerebral accumulation of amyloid-β (Aβ) initiates molecular and cellular cascades that lead to Alzheimer’s disease (AD). However, amyloid deposition does not invariably lead to dementia. Amyloid-positive but cognitively unaffected (AP-CU) individuals present widespread amyloid pathology,… read more here.

Keywords: brain; single plaque; plaque analysis; plaque ... See more keywords

Integrative Single-Cell Analysis Reveals Transcriptional and Epigenetic Regulatory Features of Clear Cell Renal Cell Carcinoma

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2 Published in 2023 at "Cancer Research"

DOI: 10.1158/0008-5472.can-22-2224

Abstract: A comprehensive analysis of gene expression and DNA regulation in ccRCC using scATAC-seq and scRNA-seq reveals the DNA regulatory programs of ccRCC at the single-cell level. read more here.

Keywords: cell; integrative single; single cell; analysis reveals ... See more keywords

Integrative single-cell chromatin and transcriptome analysis of human plasma cell differentiation

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0 Published in 2024 at "Blood"

DOI: 10.1182/blood.2023023237

Abstract: Key Points • Our results illustrate a complex and dynamic pattern of epigenetic and transcriptomic modifications in early PC genesis.• Preplasmablasts already undergo epigenetic remodeling related to mature PC together with unfolded protein response priming… read more here.

Keywords: cell chromatin; single cell; cell; integrative single ... See more keywords

Integrative Single-Cell Transcriptomic Analysis of Human Fetal Thymocyte Development

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0 Published in 2021 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2021.679616

Abstract: Intrathymic differentiation of T lymphocytes begins as early as intrauterine stage, yet the T cell lineage decisions of human fetal thymocytes at different gestational ages are not currently understood. Here, we performed integrative single-cell analyses… read more here.

Keywords: integrative single; thymocyte; human fetal; thymocyte development ... See more keywords