The Integrator complex at the crossroad of coding and noncoding RNA.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2020.11.003
Abstract: Genomic transcription is fundamental to all organisms. In metazoans, the Integrator complex is required for endonucleolytic processing of noncoding RNAs, regulation of RNA polymerase II pause-release, and premature transcription attenuation at coding genes. Recent insights… read more here.
Keywords: complex crossroad; integrator complex; noncoding rna; crossroad coding ... See more keywords
An analog-digital integrator for EAST long pulse discharge
Sign Up to like & getrecommendations! Published in 2021 at "Fusion Engineering and Design"
DOI: 10.1016/j.fusengdes.2021.112255
Abstract: Abstract As one of the key electronic instruments for the experiment of long pulse plasma discharge, the integrator is required to work stably in complex and changeable electromagnetic environments. For the integrator of real-time drift… read more here.
Keywords: integrator east; discharge; integrator; analog digital ... See more keywords
Integrator is a genome-wide attenuator of non-productive transcription.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.12.014
Abstract: Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the cleavage and polyadenylation (CPA) and integrator (INT) complexes originally found to act at the ends of protein-coding and small nuclear RNA (snRNA)… read more here.
Keywords: genome wide; transcription; int; non productive ... See more keywords
Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2022.02.006
Abstract: N6-methyladenosine (m6A) methylation is co-transcriptionally deposited on mRNA, but a possible role of m6A on transcription remains poorly understood. Here, we demonstrate that the METTL3/METTL14/WTAP m6A methyltransferase complex (MTC) is localized to many promoters and… read more here.
Keywords: m6a modification; promoters enhancers; integrator; m6a ... See more keywords
The role of pallidum in the neural integrator model of cervical dystonia
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2019.01.011
Abstract: Dystonia is the third most common movement disorder affecting three million people worldwide. Cervical dystonia is the most common form of dystonia. Despite common prevalence the pathophysiology of cervical dystonia is unclear. Traditional view is… read more here.
Keywords: neural integrator; integrator; cervical dystonia; role ... See more keywords
Design and implementation of second-order microwave integrator
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Electronics"
DOI: 10.1080/00207217.2019.1636308
Abstract: ABSTRACT In this paper, a new design methodology is developed for the implementation of a second-order microwave integrator on microstrip circuit. Firstly, an existing digital first-order integrator with best magnitude and phase performance is adopted… read more here.
Keywords: order; second order; integrator; order microwave ... See more keywords
Hybrid symplectic integrators for planetary dynamics
Sign Up to like & getrecommendations! Published in 2019 at "Monthly Notices of the Royal Astronomical Society"
DOI: 10.1093/mnras/stz769
Abstract: Hybrid symplectic integrators such as MERCURY are widely used to simulate complex dynamical phenomena in planetary dynamics that could otherwise not be investigated. A hybrid integrator achieves high accuracy during close encounters by using a high-order… read more here.
Keywords: planetary dynamics; hybrid symplectic; symplectic integrators; integrators planetary ... See more keywords
SUMO conjugation regulates the activity of the Integrator complex
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1055
Abstract: RNA pol II transcribes snRNA genes in close proximity to Cajal bodies, subnuclear compartments that depend on the SUMO isopeptidase USPL1 for their assembly. We show here that overexpression of USPL1 alters snRNA 3’-end cleavage,… read more here.
Keywords: integrator; integrator complex; sumo conjugation; activity ... See more keywords
Exponential Bhatnagar-Gross-Krook integrator for multiscale particle-based kinetic simulations.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review. E"
DOI: 10.1103/physreve.106.025303
Abstract: Despite the development of an extensive toolbox of multiscale rarefied flow simulators, such simulations remain challenging due to the significant disparity of collisional and macroscopic spatiotemporal scales. Our study offers a novel and consistent numerical… read more here.
Keywords: bhatnagar gross; multiscale; integrator; exponential bhatnagar ... See more keywords
Design of a Miniaturized Broadband Silicon Hybrid Plasmonic Temporal Integrator for Ultrafast Optical Signal Processing
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Lightwave Technology"
DOI: 10.1109/jlt.2020.2969424
Abstract: A fractional-order silicon hybrid plasmonic temporal integrator with considerably wide full-width at half- maximum (FWHM) bandwidth of ∼1 THz, higher than the previously reported photonic temporal integrators, and noticeably compact footprint of ∼5 μm × 3 μm is… read more here.
Keywords: temporal integrator; hybrid plasmonic; silicon hybrid; plasmonic temporal ... See more keywords
A 77.3-dB SNDR 62.5-kHz Bandwidth Continuous-Time Noise-Shaping SAR ADC With Duty-Cycled Gm-C Integrator
Sign Up to like & getrecommendations! Published in 2023 at "IEEE Journal of Solid-State Circuits"
DOI: 10.1109/jssc.2022.3227678
Abstract: This article presents a first-order continuous-time (CT) noise-shaping successive-approximation-register (NS-SAR) analog-to-digital converter (ADC). Different from other NS-SAR ADCs in literature, which are discrete-time (DT), this ADC utilizes a CT Gm-C integrator to realize an inherent… read more here.
Keywords: integrator; sar adc; noise; continuous time ... See more keywords