Blockage of Osteopontin-Integrin β3 Signaling in Infrapatellar Fat Pad Attenuates Osteoarthritis in Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300897
Abstract: The knowledge of osteoarthritis (OA) has nowadays been extended from a focalized cartilage disorder to a multifactorial disease. Although recent investigations have reported that infrapatellar fat pad (IPFP) can trigger inflammation in the knee joint,… read more here.
Keywords: rgd nanogel; integrin signaling; integrin; sirna cd61 ... See more keywords
Extracellular calcium regulates the adhesion and migration of osteoclasts via integrin αvβ 3/Rho A/Cytoskeleton signaling
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.11033
Abstract: Integrin αvβ3 is a transmembrane integrin, which can initiate osteoclasts’ attachment on bones, leading to downward signaling pathways and subsequent bone resorption. Different calcium concentrations have been reported to have an influence on the activation… read more here.
Keywords: cytoskeleton; extracellular calcium; adhesion migration; integrin ... See more keywords
Development of Integrin Targeting Chimeras (ITACs) for the Lysosomal Degradation of Extracellular Proteins
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202300643
Abstract: The emerging of lysosomal targeting chimera (LYTAC) expands the field of targeted protein degradation (TPD) to include the extracellular proteins for precise depletion. However, most of the reported LYTACs either induce ubiquitous degradation of the… read more here.
Keywords: extracellular proteins; degradation; integrin; targeting chimeras ... See more keywords
Integrin β6 expression in colorectal cancer cells promotes liver metastasis through enhanced adhesion to endothelial fibronectin
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Cancer"
DOI: 10.1002/ijc.35504
Abstract: Integrin β6 is associated with poor prognosis in colorectal cancer (CRC) patients, with metastasis being a crucial determinant. Capillary endothelial cells (EC) in the liver and lung are the primary sites of contact for circulating… read more here.
Keywords: cancer; integrin; tumour cells; expression ... See more keywords
An O‐Glycosylation of Fibronectin Mediates Hepatic Osteodystrophy Through α4β1 Integrin
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.2916
Abstract: Patients with cholestatic liver disease experience increased fracture risk. Higher circulating levels of a fibronectin isoform called oncofetal fibronectin (oFN) were detected in a subset of such patients. Administering this isoform to mice suppresses osteoblast… read more here.
Keywords: hepatic osteodystrophy; fibronectin; integrin; glycosylation ... See more keywords
Positive effect of Astragaloside IV on neurite outgrowth via talin‐dependent integrin signaling and microfilament force
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30002
Abstract: Integrin plays a prominent role in neurite outgrowth by transmitting both mechanical and chemical signals. Integrin expression is closely associated with Astragaloside IV (AS‐IV), the main component extracted from Astragali radix, which has a positive… read more here.
Keywords: neurite outgrowth; integrin; positive effect; microfilament force ... See more keywords
Frontline Science: The expression of integrin αDβ2 (CD11d/CD18) on neutrophils orchestrates the defense mechanism against endotoxemia and sepsis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3hi0820-529rr
Abstract: Neutrophil‐macrophage interplay is a fine‐tuning mechanism that regulates the innate immune response during infection and inflammation. Cell surface receptors play an essential role in neutrophil and macrophage functions. The same receptor can provide different outcomes… read more here.
Keywords: integrin; sepsis; defense mechanism; mechanism endotoxemia ... See more keywords
Involvement of Integrin β3 O‐Glycosylation in Human Cytomegalovirus Internalization Into Fibroblasts
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70536
Abstract: Glycosylation of viral receptors is essential during the initial steps of viral infection. While integrin β3 has been recognized as a cellular receptor facilitating human cytomegalovirus (hCMV) entry into fibroblasts, the specific contribution of its… read more here.
Keywords: internalization fibroblasts; integrin; internalization; human cytomegalovirus ... See more keywords
The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti‐integrin therapies
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21601
Abstract: Inflammatory bowel disease (IBD) is characterized by uncontrolled inflammation in the gastrointestinal tract. The underlying pathobiology of IBD includes an increase in infiltrating gut‐homing lymphocytes. Although lymphocyte homing is typically a tightly regulated and stepwise… read more here.
Keywords: inflammatory bowel; approved investigational; bowel disease; integrin ... See more keywords
Dichotomous role of integrin‐β5 in lung endothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12156
Abstract: Abstract Pulmonary arterial hypertension (PAH) is a progressive, devastating disease, and its main histological manifestation is an occlusive pulmonary arteriopathy. One important functional component of PAH is aberrant endothelial cell (EC) function including apoptosis‐resistance, unchecked… read more here.
Keywords: integrin; role integrin; lung endothelial; expression ... See more keywords
Fibronectin-integrin signaling regulates PLVAP localization at endothelial fenestrae by microtubule stabilization.
Sign Up to like & getrecommendations! Published in 2021 at "Cell and tissue research"
DOI: 10.1007/s00441-020-03326-2
Abstract: Endothelial fenestrae are the transcellular pores existing on the capillary walls which are organized in clusters referred to as sieve plates. They are also divided by a diaphragm consisting of plasmalemma vesicle-associated protein (PLVAP). In… read more here.
Keywords: microtubule; endothelial fenestrae; integrin; plvap ... See more keywords