Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104469
Abstract: Tendinopathy is a common tendon disorder that causes pain and impairs function. It is the most common reason for consultation with musculoskeletal specialists. The available therapies for tendinopathy are limited in number and efficacy and… read more here.
Keywords: inhibition integrin; activation tgf; tgf; activation ... See more keywords
Integrin activation enables rapid detection of functional Vδ1+ and Vδ2+ γδ T cells
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149682
Abstract: Conformational change of the β2 integrin lymphocyte function‐associated antigen 1 (LFA‐1) is an early marker of T cell activation. A protocol using the mAb clone m24 recognizing the active, extended high‐affinity conformation has been previously… read more here.
Keywords: activation; activation enables; detection; functional cells ... See more keywords
CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.07.008
Abstract: CD47 acts as a "don't eat me" signal that protects cells from phagocytosis by binding and activating its receptor SIPRA on macrophages. CD47 suppresses multiple different pro-engulfment "eat me" signals, including immunoglobulin G (IgG), complement,… read more here.
Keywords: phagocytosis; cd47; cd47 ligation; sirpa ... See more keywords
Tensins: Bridging AMP-Activated Protein Kinase with Integrin Activation.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2017.06.004
Abstract: Integrin activation is essential for cell adhesion and for connecting the extracellular matrix to the actin cytoskeleton. Thus, inappropriate integrin activation has been linked to several diseases, including cancer. Recent insights demonstrate that the main… read more here.
Keywords: integrin activation; activated protein; activation; protein kinase ... See more keywords
Tension Enhances the Binding Affinity of β1 Integrin by Clamping Talin Tightly: An Insight from Steered Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00963
Abstract: Integrin activation is a predominant step for cell-cell and cell-ECM interactions. Talin and Kindlin are mechanosensitive adaptor proteins that bind to the integrin cytoplasmic tail and mediate integrin activation, cytoskeleton rearrangement, and focal adhesion assembly.… read more here.
Keywords: cell; integrin; tension; talin ... See more keywords
Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability
Sign Up to like & getrecommendations! Published in 2017 at "Nature materials"
DOI: 10.1038/nmat4954
Abstract: Integrin binding to bioengineered hydrogel scaffolds is essential for tissue regrowth and regeneration, yet not all integrin binding can lead to tissue repair. Here, we show that through engineering hydrogel materials to promote α3/α5β1 integrin… read more here.
Keywords: controlled integrin; permeability; integrin activation; integrin binding ... See more keywords
Integrin activation by talin, kindlin and mechanical forces
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0234-9
Abstract: Integrins are the major family of adhesion molecules that mediate cell adhesion to the extracellular matrix. They are essential for embryonic development and influence numerous diseases, including inflammation, cancer cell invasion and metastasis. In this… read more here.
Keywords: mechanical forces; kindlin mechanical; talin kindlin; integrin activation ... See more keywords
Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms
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DOI: 10.1093/hmg/ddac163
Abstract: Abstract Adhesion of cells to the extracellular matrix (ECM) must be exquisitely coordinated to enable development and tissue homeostasis. Cell–ECM interactions are regulated by multiple signalling pathways that coordinate the activation state of the integrin… read more here.
Keywords: adhesion; clinical symptoms; integrin activation; multifaceted clinical ... See more keywords
Differential Use of Rap1 Effectors for Integrin Activation in Platelets and Lymphocytes
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DOI: 10.1182/blood-2020-142720
Abstract: Rap1 is a major convergence point of the platelet and lymphocyte signaling pathways that result in talin1 binding to the integrin β-cytoplasmic domain and consequent integrin activation, effective hemostasis and immune functions. The nature of… read more here.
Keywords: integrin activation; r35e r118e; rap1; activation ... See more keywords
Talin1 is the Principal Platelet Rap1 Effector of Integrin Activation.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020005348
Abstract: Rap1 is a major convergence point of the platelet signaling pathways that result in talin1 binding to the integrin b cytoplasmic domain and consequent integrin activation, platelet aggregation, and effective hemostasis. The nature of the… read more here.
Keywords: talin1 principal; platelet; rap1; integrin activation ... See more keywords
Talin, a Rap1 effector for integrin activation at the plasma membrane, also promotes Rap1 activity by disrupting sequestration of Rap1 by SHANK3
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cell Science"
DOI: 10.1242/jcs.263595
Abstract: ABSTRACT Talin regulates the adhesion and migration of cells in part by promoting the affinity of integrins for extracellular matrix proteins, a process that in cells such as endothelial cells and platelets requires the direct… read more here.
Keywords: rap1; gtp; talin; activation ... See more keywords