Impact of UV- and carbodiimide-based crosslinking on the integrin-binding properties of collagen-based materials: Integrin binding to UV- and carbodiimide-crosslinked collagen.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.09.046
Abstract: Collagen constructs are widely used for tissue engineering. These are frequently chemically crosslinked, using EDC, to improve their stability and tailor their physical properties. Although generally biocompatible, chemical crosslinking can modify crucial amino acid side… read more here.
Keywords: carbodiimide; cell; collagen based; integrin binding ... See more keywords
Covalent Capture of a Collagen Mimetic Peptide with an Integrin-Binding Motif.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00155
Abstract: Collagen mimetic peptides (CMPs) are an excellent model to study the structural and biological properties of the extracellular matrix (ECM) due to ease of synthesis and variability in sequence. To ensure that synthetic materials accurately… read more here.
Keywords: covalent capture; integrin binding; peptide; collagen mimetic ... See more keywords
Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability
Sign Up to like & getrecommendations! Published in 2017 at "Nature materials"
DOI: 10.1038/nmat4954
Abstract: Integrin binding to bioengineered hydrogel scaffolds is essential for tissue regrowth and regeneration, yet not all integrin binding can lead to tissue repair. Here, we show that through engineering hydrogel materials to promote α3/α5β1 integrin… read more here.
Keywords: controlled integrin; permeability; integrin activation; integrin binding ... See more keywords
Integrin binding: Sticking around vessels.
Sign Up to like & getrecommendations! Published in 2017 at "Nature materials"
DOI: 10.1038/nmat4977
Abstract: A study demonstrates that controlled integrin binding on a biomaterial was capable of promoting vascular cell sprouting and formation of a non-leaky blood vessel network in a healthy and diseased state. read more here.
Keywords: sticking around; integrin binding; around vessels; binding sticking ... See more keywords
Oligomeric state, hydrodynamic properties and target recognition of human Calcium and Integrin Binding protein 2 (CIB2)
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-51573-3
Abstract: Calcium- and Integrin-Binding protein 2 (CIB2) is a small and ubiquitously expressed protein with largely unknown biological function but ascertained role in hearing physiology and disease. Recent studies found that CIB2 binds Ca2+ with moderate… read more here.
Keywords: calcium integrin; integrin; binding protein; integrin binding ... See more keywords
Soluble Thy-1 reverses lung fibrosis via its integrin-binding motif.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.131152
Abstract: Loss of Thy-1 expression in fibroblasts correlates with lung fibrogenesis; however, the clinical relevance of therapeutic targeting of myofibroblasts via Thy-1-associated pathways remains to be explored. Using single (self-resolving) or repetitive (nonresolving) intratracheal administration of… read more here.
Keywords: thy reverses; fibrosis; integrin; reverses lung ... See more keywords
Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.151583
Abstract: Osteosarcoma (OS) is a lethal disease with few known targeted therapies. Here, we show that decreased ATRX expression is associated with more aggressive tumor cell phenotypes, including increased growth, migration, invasion, and metastasis. These phenotypic… read more here.
Keywords: aggressive features; promotes aggressive; integrin binding; loss ... See more keywords
Calcium- and Integrin-Binding Protein 2 (CIB2) in Physiology and Disease: Bright and Dark Sides
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073552
Abstract: Calcium- and integrin-binding protein 2 (CIB2) is a small EF-hand protein capable of binding Mg2+ and Ca2+ ions. While its biological function remains largely unclear, an increasing number of studies have shown that CIB2 is… read more here.
Keywords: binding protein; integrin binding; physiology; protein cib2 ... See more keywords
Bruch’s-Mimetic Nanofibrous Membranes Functionalized with the Integrin-Binding Peptides as a Promising Approach for Human Retinal Pigment Epithelium Cell Transplantation
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DOI: 10.3390/molecules27041429
Abstract: Background: This study aimed to develop an ultrathin nanofibrous membrane able to, firstly, mimic the natural fibrous architecture of human Bruch’s membrane (BM) and, secondly, promote survival of retinal pigment epithelial (RPE) cells after surface… read more here.
Keywords: rpe cells; rpe; integrin binding; retinal pigment ... See more keywords
Integrin binding peptides facilitate growth and interconnected vascular-like network formation of rat primary cortical vascular endothelial cells in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.355760
Abstract: Neovascularization and angiogenesis in the brain are important physiological processes for normal brain development and repair/regeneration following insults. Integrins are cell surface adhesion receptors mediating important function of cells such as survival, growth and development… read more here.
Keywords: culture; brain microvascular; endothelial cells; growth ... See more keywords