GATA1-deficient human pluripotent stem cells generate neutrophils with improved antifungal immunity that is mediated by the integrin CD18
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DOI: 10.1371/journal.ppat.1012654
Abstract: Neutrophils are critical for host defense against fungi. However, the short life span and lack of genetic tractability of primary human neutrophils has limited in vitro analysis of neutrophil-fungal interactions. Human induced pluripotent stem cell… read more here.
Keywords: antifungal immunity; pluripotent stem; integrin cd18; gata1 ... See more keywords