Distinct roles of kindlin-3 and talin-1 in neutrophil beta2 integrin clustering
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DOI: 10.1152/physiol.2023.38.s1.5711459
Abstract: Neutrophils are the most abundant leukocytes in human blood. Neutrophil malfunction may cause various immunological diseases. Beta2 integrins are critical for neutrophil recruitment. Kindlin-3 and talin-1 are important regulators for beta2 integrin activation. We have… read more here.
Keywords: beta2 integrin; physiology; kindlin talin; integrin clustering ... See more keywords
The βI domain promotes active β1 integrin clustering into mature adhesion sites
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DOI: 10.26508/lsa.202201388
Abstract: Mana et al show that the extracellular headpiece βI domain is involved in conformationally active β1 integrin clustering, fibrillar adhesion formation, incorporation of soluble fibronectin dimers into fibrillar polymers, and extracellular matrix–dependent endothelial cell migration.… read more here.
Keywords: adhesion; domain promotes; integrin clustering; domain ... See more keywords
Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation
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DOI: 10.7554/elife.72588
Abstract: Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated compartments where cells sense environmental cues. The physical mechanisms and molecular interactions that mediate initial IAC formation are unclear. We found that both p130Cas (‘Cas’) and Focal adhesion… read more here.
Keywords: adhesion; phase separation; integrin clustering; phase ... See more keywords