Co-targeting of EGF receptor and neuropilin-1 overcomes cetuximab resistance in pancreatic ductal adenocarcinoma with integrin β1-driven Src-Akt bypass signaling
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DOI: 10.1038/onc.2016.407
Abstract: Pancreatic ductal adenocarcinoma (PDAC) cells usually overexpress the epidermal growth factor receptor (EGFR); however, most are resistant to the anti-EGFR monoclonal antibody, cetuximab. In this study, we report that the molecular mechanism of resistance to… read more here.
Keywords: src akt; integrin driven; pdac cells; active integrin ... See more keywords
Abstract 80: Integrin driven adhesion in ovarian cancer
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DOI: 10.1158/1538-7445.am2025-80
Abstract: Ovarian cancer is the fifth leading cause of cancer-related deaths in women due to late-stage diagnosis, reducing the survival rate to 30%. During dissemination, ovarian cancer cellsexfoliate from the primary tumor and aggregate to form… read more here.
Keywords: cancer; driven adhesion; adhesion ovarian; adhesion ... See more keywords