MGMT promoter methylation is not correlated with integrin expression in malignant gliomas: clarifying recent clinical trial results
Sign Up to like & getrecommendations! Published in 2018 at "Medical Oncology"
DOI: 10.1007/s12032-018-1162-z
Abstract: Integrin alpha-v-beta-3 (αvβ3) is important for invasive tumor growth and angiogenesis in glioblastomas (GBM). However, recent clinical trials on inhibition of this integrin led to ambiguous results whether patients with methylated or unmethylated 6O-methylguanine methyltransferase… read more here.
Keywords: integrin expression; mgmt promoter; expression;
Integrin α7 expression is increased in asthmatic patients and its inhibition reduces Kras protein abundance in airway smooth muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46260-2
Abstract: Airway smooth muscle (ASM) cells exhibit plastic phenotypic behavior marked by reversible modulation and maturation between contractile and proliferative phenotypic states. Integrins are a class of transmembrane proteins that have been implicated as novel therapeutic… read more here.
Keywords: asm; integrin expression; smooth muscle; inhibition ... See more keywords
Wnt5A modulates integrin expression in a receptor-dependent manner in ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-85356-6
Abstract: Wnt5A signals through various receptors that confer versatile biological functions. Here, we used Wnt5A overexpressing human ovarian SKOV-3 and OVCAR-3 stable clones for assessing integrin expression, cell proliferation, migration, invasion, and the ability of multicellular… read more here.
Keywords: integrin expression; expression; ovarian cancer; expression levels ... See more keywords
Integrin expression and adhesivity to fibronectin in primary acute myeloid leukemia cells: Impact of NPM1 and FLT3 mutations
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DOI: 10.1111/ejh.13488
Abstract: Interaction of leukemia cells with the bone marrow extracellular matrix promotes cell survival and resistance to chemotherapy. In this work, we analyzed integrin expression and adhesivity to fibronectin in primary cells from patients with acute… read more here.
Keywords: integrin expression; leukemia cells; adhesivity fibronectin; expression adhesivity ... See more keywords
Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin α2β1 expression
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12793
Abstract: Advanced prostate cancer often develops into bone metastasis, which is characterized by aberrant bone formation with chronic pain and lower chances of survival. No treatment exists as yet for osteoblastic bone metastasis in prostate cancer.… read more here.
Keywords: prostate cancer; integrin expression; prostate; osteoblastic prostate ... See more keywords
Cardiac αVβ3 integrin expression following acute myocardial infarction in humans
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DOI: 10.1136/heartjnl-2016-310115
Abstract: Objective Maladaptive repair contributes towards the development of heart failure following myocardial infarction (MI). The αvβ3 integrin receptor is a key mediator and determinant of cardiac repair. We aimed to establish whether αvβ3 integrin expression… read more here.
Keywords: integrin expression; fluciclatide uptake; 18f fluciclatide; myocardial infarction ... See more keywords
Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis
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DOI: 10.1371/journal.pone.0220008
Abstract: Anti-α4β7 therapy with vedolizumab (VDZ) has been suggested as possible immune intervention in HIV. Relatively little is known about the α4β7-integrin (α4β7) expression of different T-cell subsets in different anatomical compartments of healthy individuals, patients… read more here.
Keywords: integrin expression; cell subsets; ulcerative colitis; expression ... See more keywords
CTLs From Patients With Atherosclerosis Show Elevated Adhesiveness and Distinct Integrin Expression Patterns on 2D Substrates
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.891916
Abstract: Atherosclerosis is the major cause of cardiovascular disease that is characterized by plaque formation in the blood vessel wall. Atherosclerotic plaques represent sites of chronic inflammation with diverse cell content that is shifted toward the… read more here.
Keywords: patients atherosclerosis; integrin expression; healthy donors; expression ... See more keywords