Involvement of PDGFR‐integrin interactions in the regulation of anoikis resistance in glioblastoma progression
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DOI: 10.1002/cbin.12257
Abstract: The interactions between platelet‐derived growth factor/PDGF receptor and integrin signaling are crucial for cells to respond to extracellular stimuli. Integrin interactions with PDGFR within the lipid rafts activate downstream cellular signaling pathways that regulate cell… read more here.
Keywords: anoikis resistance; glioblastoma progression; pdgfr integrin; cell ... See more keywords
Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition
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DOI: 10.1093/cvr/cvaf021
Abstract: Abstract Aims In this study, we aimed to uncover genes associated with stressed cardiomyocytes by combining single-cell transcriptomic data sets from failing cardiac tissue from both humans and mice. Methods and results Our bioinformatic analysis… read more here.
Keywords: failure; integrin interactions; expression; sorbs2 ... See more keywords
Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
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DOI: 10.7554/elife.86971
Abstract: Pancreatic ductal adenocarcinoma (PDAC) continues to show no improvement in survival rates. One aspect of PDAC is elevated ATP levels, pointing to the purinergic axis as a potential attractive therapeutic target. Mediated in part by… read more here.
Keywords: cancer; invasion; cancer cell; integrin interactions ... See more keywords