Chiral β-lactam-based integrin ligands through Lipase-catalysed kinetic resolution and their enantioselective receptor response.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.102975
Abstract: Obtainment and testing of pure enantiomers are of great importance for bioactive compounds, because of the assessed implications of enantioselectivity in receptor-mediated responses. Herein we evaluated the use of biocatalysis to obtain enantiomerically pure β-lactam… read more here.
Keywords: receptor; kinetic resolution; integrin ligands; chiral lactam ... See more keywords
Molecular Delivery of Cytotoxic Agents via Integrin Activation
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13020299
Abstract: Simple Summary Chemotherapy constituted a cornerstone in cancer treatment, but it suffers from non-selective drug cytotoxicity; an active drug targeting exerted by covalent conjugates between antitumor agents and some integrin ligands should have a more… read more here.
Keywords: cytotoxic; molecular delivery; covalent conjugates; cytotoxic agents ... See more keywords