β1-Integrin-Mediated Adhesion Is Lipid-Bilayer Dependent.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.07.010
Abstract: Integrin-mediated adhesion is a central feature of cellular adhesion, locomotion, and endothelial cell mechanobiology. Although integrins are known to be transmembrane proteins, little is known about the role of membrane biophysics and dynamics in integrin… read more here.
Keywords: mediated adhesion; adhesion; integrin; migration ... See more keywords
The integrin-mediated adhesive complex in the ancestor of animals, fungi, and amoebae
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2021.04.076
Abstract: Integrins are transmembrane receptors that activate signal transduction pathways upon extracellular matrix binding. The integrin-mediated adhesive complex (IMAC) mediates various cell physiological processes. Although the IMAC was thought to be specific to animals, in the… read more here.
Keywords: mediated adhesive; adhesive complex; complex ancestor; integrin mediated ... See more keywords
Exploring Integrin-Mediated Force Transmission during Confined Cell Migration by DNA-Based Tension Probes.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04962
Abstract: Mechanical forces have profound effects on the morphology and migration of cells in a two-dimensional environment. However, cells in vivo mostly migrate in three-dimensional space while physically constrained, and the mechanism by which cellular dynamic… read more here.
Keywords: based tension; tension probes; migration; tension ... See more keywords
Structure–Activity Relationships of RGD-Containing Peptides in Integrin αvβ5-Mediated Cell Adhesion
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c06540
Abstract: The RGD motif is a cell adhesion sequence that binds to integrins, a receptor family for extracellular matrix proteins. We previously reported that the RGDX1X2 sequence, where X1X2 is VF or NY, is required for… read more here.
Keywords: adhesion; cell adhesion; containing peptides; mediated cell ... See more keywords
Targeting the Achilles’ heel of cancer cells via integrin-mediated delivery of ROS-generating dihydrolipoamide dehydrogenase
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0775-9
Abstract: Cancer cells frequently exhibit higher levels of reactive oxygen species (ROS) than normal cells and when ROS levels increase beyond a cellular tolerability threshold, cancer cell death is enhanced. The mitochondrial dihydrolipoamide dehydrogenase (DLDH) is… read more here.
Keywords: dihydrolipoamide dehydrogenase; delivery; cancer cells; cancer ... See more keywords
Manganese supplementation of orthopedic implants: a new strategy for enhancing integrin-mediated cellular responses
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials Science"
DOI: 10.1039/d2bm02165j
Abstract: Integrin-mediated osteoblast adhesion to adsorbed extracellular ligands on orthopedic implants is crucial for the subsequent osteoblast behaviors and ultimate osseointegration. Considerable research efforts have focused on the development of implant... read more here.
Keywords: manganese supplementation; implants new; supplementation orthopedic; orthopedic implants ... See more keywords
Integrin-mediated adhesions in regulation of cellular senescence
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aay3909
Abstract: βPIX and GIT control cellular senescence through integrin signaling. Bioinformatic and functional data link integrin-mediated cell adhesion to cellular senescence; however, the significance of and molecular mechanisms behind these connections are unknown. We now report… read more here.
Keywords: integrin signaling; senescence; cellular senescence; integrin mediated ... See more keywords
The Transmembrane Mucin MUC1 Facilitates β1-Integrin-Mediated Bacterial Invasion
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.03491-20
Abstract: Bacteria can exploit membrane receptor integrins for cellular invasion, either by direct binding of bacterial adhesins or utilizing extracellular matrix components. MUC1 is a large transmembrane glycoprotein expressed by most epithelial cells that can have… read more here.
Keywords: muc1; integrin mediated; invasion; receptor ... See more keywords
A Small GTPase, RhoA, Inhibits Bacterial Infection Through Integrin Mediated Phagocytosis in Invertebrates
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01928
Abstract: The Ras GTPase superfamily, including more than 100 members, plays a vital role in a number of cellular processes, such as cytoskeleton recombination, gene expression, and signaling pathway regulation. Some members of the superfamily participate… read more here.
Keywords: mediated phagocytosis; phagocytosis; mjrhoa; shrimp ... See more keywords
Adhesions Assemble!—Autoinhibition as a Major Regulatory Mechanism of Integrin-Mediated Adhesion
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2019.00144
Abstract: The advent of cell-cell and cell-extracellular adhesion enabled cells to interact in a coherent manner, forming larger structures and giving rise to the development of tissues, organs and complex multicellular life forms. The development of… read more here.
Keywords: mediated adhesion; adhesion; integrin mediated; cell ... See more keywords
Integrin-Mediated Tumorigenesis and Its Therapeutic Applications
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.812480
Abstract: Integrins, a family of adhesion molecules generally exist on the cell surface, are essential for regulating cell growth and its function. As a bi-directional signaling molecule, they mediate cell-cell and cell-extracellular matrix interaction. The recognitions… read more here.
Keywords: mediated tumorigenesis; therapeutic applications; cell; tumorigenesis therapeutic ... See more keywords