CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration
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DOI: 10.1126/scisignal.aav5938
Abstract: The cell surface peptidase CD13 coordinates β1 integrin recycling to promote cell migration. Recycle and go forth! Cell migration and motility are critical to embryonic development, immunity, and tissue repair, but uncontrolled migration can lead… read more here.
Keywords: cell migration; surface; integrin recycling; migration ... See more keywords
GGA2 and RAB13 promote activity-dependent β1-integrin recycling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.233387
Abstract: ABSTRACT β1-integrins mediate cell–matrix interactions and their trafficking is important in the dynamic regulation of cell adhesion, migration and malignant processes, including cancer cell invasion. Here, we employ an RNAi screen to characterize regulators of… read more here.
Keywords: gga2 rab13; active integrin; integrin; integrin recycling ... See more keywords