Blockage of Osteopontin-Integrin β3 Signaling in Infrapatellar Fat Pad Attenuates Osteoarthritis in Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300897
Abstract: The knowledge of osteoarthritis (OA) has nowadays been extended from a focalized cartilage disorder to a multifactorial disease. Although recent investigations have reported that infrapatellar fat pad (IPFP) can trigger inflammation in the knee joint,… read more here.
Keywords: rgd nanogel; integrin signaling; integrin; sirna cd61 ... See more keywords
Effects of lentivirus‐mediated silencing of Periostin on tumor microenvironment and bone metastasis via the integrin‐signaling pathway in lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.05.030
Abstract: &NA; The study aims to investigate the effects of Periostin gene silencing on tumor microenvironment and bone metastasis via the integrin‐signaling pathway in lung cancer (LC). LC patients were divided into bone metastasis and non‐bone… read more here.
Keywords: integrin signaling; periostin; metastasis; signaling pathway ... See more keywords
Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2019.12.009
Abstract: Summary The Mixed Lineage Leukemia (MLL1, KMT2A) gene is critical for development and maintenance of hematopoietic stem cells (HSCs), however, whether this protein is limiting for HSC development is unknown due to lack of physiologic… read more here.
Keywords: rac rho; stem; rho integrin; integrin signaling ... See more keywords
Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16795-4
Abstract: Proper storage of excessive dietary fat into subcutaneous adipose tissue (SAT) prevents ectopic lipid deposition-induced insulin resistance, yet the underlying mechanism remains unclear. Here, we identify angiopoietin-2 (Angpt2)–integrin α5β1 signaling as an inducer of fat… read more here.
Keywords: integrin signaling; ectopic lipid; fatty acid; insulin resistance ... See more keywords
Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-67814-9
Abstract: Pancreatic cancer, one of the deadliest human malignancies, has a dismal 5-year survival rate of 9%. KRAS is the most commonly mutated gene in pancreatic cancer, but clinical agents that directly target mutant KRAS are… read more here.
Keywords: integrin signaling; mek inhibition; inhibition; pancreatic cancer ... See more keywords
Integrin-mediated adhesions in regulation of cellular senescence
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aay3909
Abstract: βPIX and GIT control cellular senescence through integrin signaling. Bioinformatic and functional data link integrin-mediated cell adhesion to cellular senescence; however, the significance of and molecular mechanisms behind these connections are unknown. We now report… read more here.
Keywords: integrin signaling; senescence; cellular senescence; integrin mediated ... See more keywords
Abstract A08: PI3Kbeta regulates beta-1 integrin signaling in invadopodia through formation of PI(3,4)P2
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.pi3k-mtor18-a08
Abstract: The PI3Kbeta isoform of PI 3-kinase, which is activated downstream from both RTKs and GPCRs, is an important regulator of invadopodia formation. We have previously reported that in MDA-MB-231 breast cancer cells, replacement of endogenous… read more here.
Keywords: pi3kbeta; invadopodia formation; beta integrin; integrin signaling ... See more keywords
Liver cell hydration and integrin signaling
Sign Up to like & getrecommendations! Published in 2021 at "Biological Chemistry"
DOI: 10.1515/hsz-2021-0193
Abstract: Abstract Liver cell hydration (cell volume) is dynamic and can change within minutes under the influence of hormones, nutrients, and oxidative stress. Such volume changes were identified as a novel and important modulator of cell… read more here.
Keywords: liver cell; integrin signaling; hydration integrin; cell ... See more keywords
NFκB-Induced Periostin Activates Integrin-β3 Signaling to Promote Renal Injury in GN.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016070709
Abstract: De novo expression in the kidney of periostin, a protein involved in odontogenesis and osteogenesis, has been suggested as a biomarker of renal disease. In this study, we investigated the mechanism(s) of induction and the… read more here.
Keywords: integrin signaling; periostin; periostin activates; induced periostin ... See more keywords