Integrin αvβ6‐Targeted PET/CT Imaging of Non‐Small Cell Lung Cancer with [68Ga]Ga‐Trivehexin: Improved Preoperative Lymph Node Staging and Association with Immunohistochemistry
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202508225
Abstract: Integrin αvβ6, an epithelial‐specific integrin, plays a crucial role in the development and prognosis of multiple tumors and has emerged as a potential target for cancer diagnosis and treatment. The novel integrin αvβ6‐targeted radiotracer [68Ga]Ga‐Trivehexin… read more here.
Keywords: cancer; integrin targeted; trivehexin; 68ga trivehexin ... See more keywords
Tetrac-conjugated polymersomes for integrin-targeted delivery of camptothecin to colon adenocarcinoma in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.039
Abstract: In this study, we prepared tetraiodothyroacetic acid (tetrac) conjugated PEG-PLGA polymersomes for the targeted delivery of camptothecin to colon adenocarcinoma. Tetrac, which binds to integrin αvβ3 with high affinity and specificity, was covalently conjugated to… read more here.
Keywords: microscopy; camptothecin; integrin targeted; tetrac conjugated ... See more keywords
Three Is a Magic Number: Tailored Clickable Chelators Used to Determine Optimal RGD-Peptide Multiplicity in αvβ6-Integrin Targeted 177Lu-Labeled Cancer Theranostics.
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DOI: 10.1021/acs.bioconjchem.4c00481
Abstract: The cellular adhesion receptor αvβ6-integrin is highly expressed in many cancers, e.g., pancreatic, lung, head-and-neck, cervical, bladder, and esophageal carcinoma. Multimerization of αvβ6-integrin-specific RGD peptides increases the target affinity and retention but affects biodistribution and… read more here.
Keywords: three magic; integrin targeted; number tailored; integrin ... See more keywords
Integrin-targeted quantitative optoacoustic imaging with MRI correlation for monitoring a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma
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DOI: 10.1371/journal.pone.0204930
Abstract: Purpose To investigate αvβ3-integrin-targeted optoacoustic imaging and MRI for monitoring a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma. Materials and methods Human BRAF V600E-positive melanoma xenograft (A375)-bearing Balb/c nude mice (n… read more here.
Keywords: braf mek; mek inhibitor; integrin targeted; integrin ... See more keywords
Integrin α6-Targeted Molecular Imaging of Central Nervous System Leukemia in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.812277
Abstract: Central nervous system leukemia (CNS-L) is caused by leukemic cells infiltrating into the meninges or brain parenchyma and remains the main reason for disease relapse. Currently, it is hard to detect CNS-L accurately by clinically… read more here.
Keywords: molecular imaging; mice; cns; central nervous ... See more keywords
Novel c(RGDyK)-based conjugates of POPAM and 5-fluorouracil for integrin-targeted cancer therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2017-0139
Abstract: AIM Alkylating agents and antimetabolites are cytotoxic drugs commonly used in cancer treatment. These medications are often associated with serious side effects on normal tissues and organs. METHODOLOGY To improve the pharmacological profile of the… read more here.
Keywords: cancer; integrin targeted; conjugates popam; novel rgdyk ... See more keywords