Development of Integrin Targeting Chimeras (ITACs) for the Lysosomal Degradation of Extracellular Proteins
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202300643
Abstract: The emerging of lysosomal targeting chimera (LYTAC) expands the field of targeted protein degradation (TPD) to include the extracellular proteins for precise depletion. However, most of the reported LYTACs either induce ubiquitous degradation of the… read more here.
Keywords: extracellular proteins; degradation; integrin; targeting chimeras ... See more keywords
Chemical Modifications on the αvβ6 Integrin Targeting A20FMDV2 Peptide: A Review
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DOI: 10.1002/cmdc.202400131
Abstract: Integrin proteins have received a significant increase in attention in recent scientific endeavors. The current trend uses the pre‐established knowledge that the arginyl‐glycyl‐aspartic acid (RGD) structural motif present in the A20FMDV2 peptide is highly selective… read more here.
Keywords: a20fmdv2 peptide; integrin targeting; modifications integrin; peptide review ... See more keywords
An integrin-targeting glutathione-activated zinc(II) phthalocyanine for dual targeted photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.049
Abstract: A zinc(II) phthalocyanine substituted with three 2,4-dinitrobenzenesulfonate (DNBS) groups and a cyclic arginine-glycine-aspartic acid (cRGDfK) moiety was prepared and characterized. With three strongly electron-withdrawing DNBS groups, this compound was fully quenched in terms of fluorescence… read more here.
Keywords: integrin targeting; photodynamic therapy; targeted photodynamic; zinc phthalocyanine ... See more keywords
Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14058
Abstract: Peritoneal carcinomatosis from gastric cancer represents a common recurrent gastric cancer that seriously affects the survival, prognosis, and quality of life of patients at its advanced stage. In recent years, complete cytoreduction surgery in combination… read more here.
Keywords: integrin targeting; gastric cancer; carcinomatosis gastric; cancer ... See more keywords
Synthetic Integrin-Targeting Dextran-Fc Hybrids Efficiently Inhibit Tumor Proliferation In Vitro.
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Chemistry"
DOI: 10.26083/tuprints-00019433
Abstract: Herein, we present the design, synthesis, and biological evaluation of novel integrin-targeting molecular hybrids combining RGD peptides and a potent cytotoxin presented on dextran polysaccharides. Based on an aglycosylated Fc as a centerpiece, endosomal-cleavable cytotoxic… read more here.
Keywords: synthetic integrin; integrin; hybrids efficiently; dextran hybrids ... See more keywords
In vivo evaluation of integrin αvβ6-targeting peptide in NSCLC and brain metastasis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1070967
Abstract: Introduction Integrin αvβ6, which is upregulated in malignancies and remains absent or weak in normal tissue, is a promising target in molecular imaging therapeutics. In vivo imaging of integrin αvβ6 could therefore be valuable for… read more here.
Keywords: integrin; integrin targeting; brain; sflap3 cy5 ... See more keywords