MutSĪ² regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells.
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DOI: 10.1016/j.celrep.2022.110602
Abstract: Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed "alternative lengthening of telomeres" (ALT) that relies on homologous recombination between telomeric sequences. Emerging evidence suggests that the recombinogenic nature of… read more here.
Keywords: alt; cancer cells; alt cancer; integrity alt ... See more keywords