Nucleotide sequence analysis of NPS-1 &bgr;-lactamase and a novel integron (In1427)-carrying transposon in an MDR Pseudomonas aeruginosa keratitis strain
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DOI: 10.1093/jac/dky073
Abstract: Sir, The gene encoding NPS-1 b-lactamase (blaNPS-1) was first reported on a self-transmissible plasmid of clinical isolates of Pseudomonas aeruginosa. The enzyme can hydrolyse carbenicillin, azlocillin, cefoperazone and cefsulodin, but cannot effectively hydrolyse more stable… read more here.
Keywords: nucleotide sequence; integron; resistance; transposon ... See more keywords
Cassette recruitment in the chromosomal Integron of Vibrio cholerae
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DOI: 10.1093/nar/gkab412
Abstract: Abstract Integrons confer a rapid adaptation capability to bacteria. Integron integrases are able to capture and shuffle novel functions embedded in cassettes. Here, we investigated cassette recruitment in the Vibrio cholerae chromosomal integron during horizontal… read more here.
Keywords: chromosomal integron; integron; cassette; cholerae ... See more keywords
Characterization of the novel In1059 harbouring VIM gene cassette
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DOI: 10.1186/s13756-017-0204-1
Abstract: BackgroundVIM-type enzyme encodes the most widely acquired metallo-β-lactamases in Gram- negative bacteria. To obtain current epidemiological data for integrons from enterobacteriae in hospital, the study characterizes the genetic structure in In1059 by comparison with In846… read more here.
Keywords: vim gene; integron; novel in1059; in1059 ... See more keywords
The large plasmid carried class 1 integrons mediated multidrug resistance of foodborne Salmonella Indiana
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DOI: 10.3389/fmicb.2022.991326
Abstract: Salmonella enterica serovar Indiana (S. Indiana) has aroused widespread concern as an important zoonotic pathogen. The molecular mechanism of multidrug resistance (MDR) in S. Indiana is not known and should be assessed. We aim to… read more here.
Keywords: integron; class integrons; class; indiana ... See more keywords
Integron activity accelerates the evolution of antibiotic resistance
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DOI: 10.7554/elife.62474
Abstract: Mobile integrons are widespread genetic platforms that allow bacteria to modulate the expression of antibiotic resistance cassettes by shuffling their position from a common promoter. Antibiotic stress induces the expression of an integrase that excises… read more here.
Keywords: expression; antibiotic resistance; integron; activity ... See more keywords