Intensive and Prolonged Urine Collection in Preterm Infants Reveals Three Distinct Indomethacin Metabolic Patterns: Potential Implications for Drug Dosing
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DOI: 10.1038/s41390-018-0051-7
Abstract: Interindividual variability in the development (rate and extent) of drug clearance pathways(1) may contribute to the observed 14-fold variability in indomethacin (IND) systemic exposure(2), and thus, the drug’s unpredictable efficacy and toxicity profile following standard… read more here.
Keywords: preterm; drug; preterm infants; intensive prolonged ... See more keywords