Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0865-5
Abstract: Here we describe the use of an organotypic hippocampal slice model for studying α-synuclein aggregation and inter-neuronal spreading initiated by microinjection of pre-formed α-synuclein fibrils (PFFs). PFF injection at dentate gyrus (DG) templates the formation… read more here.
Keywords: synuclein; model; neuronal spreading; inter neuronal ... See more keywords
Inter-neuronal signaling mediated by small extracellular vesicles: wireless communication?
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1187300
Abstract: Conventional inter-neuronal communication conceptualizes the wired method of chemical synapses that physically connect pre-and post-synaptic neurons. In contrast, recent studies indicate that neurons also utilize synapse-independent, hence “wireless” broadcasting-type communications via small extracellular vesicles (EVs).… read more here.
Keywords: extracellular vesicles; communication; mediated small; small extracellular ... See more keywords