Metabolic channeling of lipids via the contact zones between different organelles
Sign Up to like & getrecommendations! Published in 2024 at "BioEssays"
DOI: 10.1002/bies.202400045
Abstract: Various lipid transfer proteins (LTPs) mediate the inter‐organelle transport of lipids. By working at membrane contact zones between donor and acceptor organelles, LTPs achieve rapid and accurate inter‐organelle transfer of lipids. This article will describe… read more here.
Keywords: lipids via; channeling lipids; metabolic channeling; inter organelle ... See more keywords
Single Image Capture of Bioactive Ion Crosstalk within Inter‐Organelle Membrane Contacts at Nanometer Resolution
Sign Up to like & getrecommendations! Published in 2022 at "Small Methods"
DOI: 10.1002/smtd.202200321
Abstract: Rapid bioactive ion exchange is a form of communication that regulates a wide range of biological processes. Despite advances in super‐resolution optical microscopy, visualizing ion exchange remains challenging due to the extremely fast nature of… read more here.
Keywords: nanometer resolution; inter organelle; bioactive ion; ion ... See more keywords
Organelle homeostasis principles: How organelle quality control and inter-organelle crosstalk promote cell survival.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.03.012
Abstract: To survive, cells sense their surroundings and adapt to enable homeostasis. Studies dissecting this process reveal organizational principles, including quality-control pathways, changes to organelle shape, and inter-organelle communication, that facilitate metabolic or developmental remodeling. In… read more here.
Keywords: homeostasis; organelle homeostasis; homeostasis principles; inter organelle ... See more keywords
Alterations in Inter-organelle Crosstalk and Ca2+ Signaling through Mitochondria during Proteotoxic Stresses.
Sign Up to like & getrecommendations! Published in 2020 at "Mitochondrion"
DOI: 10.1016/j.mito.2020.12.003
Abstract: BACKGROUND Biogenesis and function of mitochondria is profoundly dependent on cytosolic translation of mitochondrial pre-proteins and its subsequent translocation and folding inside the organelle. Continuous exposure of non-native precursor proteins, exposure to damaging by-products of… read more here.
Keywords: alterations inter; ca2 signaling; mitochondrial proteotoxicity; ca2 ... See more keywords
Organelle Transporters and Inter-Organelle Communication as Drivers of Metabolic Regulation and Cellular Homeostasis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular metabolism"
DOI: 10.1016/j.molmet.2022.101481
Abstract: Spatial compartmentalization of metabolic pathways within membrane-separated organelles is key to the ability of eukaryotic cells to precisely regulate their biochemical functions. Membrane-bound organelles such as mitochondria, endoplasmic reticulum (ER) and lysosomes enable the concentration… read more here.
Keywords: communication drivers; communication; organelle communication; organelle transporters ... See more keywords
Inter-Organelle Contact Sites Mediate the Intracellular Antioxidant Activity of Platinum Nanozymes: A New Perspective on Cell–Nanoparticle Interaction and Signaling
Sign Up to like & getrecommendations! Published in 2023 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.2c22375
Abstract: The catalytic and antioxidant properties of platinum nanoparticles (PtNPs) make them promising candidates for several applications in nanomedicine. However, an open issue, still shared among most nanomaterials, is the understanding on how internalized PtNPs, which… read more here.
Keywords: ptnps; cell; contact sites; inter organelle ... See more keywords
A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets
Sign Up to like & getrecommendations! Published in 2024 at "EMBO Reports"
DOI: 10.1038/s44319-024-00266-8
Abstract: Effective intracellular communication between cellular organelles occurs at dedicated membrane contact sites (MCSs). Tether proteins are responsible for the establishment of MCSs, enabling direct communication between organelles to ensure organelle function and host cell homeostasis.… read more here.
Keywords: cbepf1; host; effector protein; inter organelle ... See more keywords
Fundamental roles for inter-organelle communication in aging
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20220519
Abstract: Advances in public health have nearly doubled life expectancy over the last century, but this demographic shift has also changed the landscape of human illness. Today, chronic and age-dependent diseases dominate the leading causes of… read more here.
Keywords: organelle interactions; roles inter; inter organelle; organelle communication ... See more keywords
Inter-organelle communication dynamically orchestrates juvenile hormone biosynthesis and female reproduction
Sign Up to like & getrecommendations! Published in 2025 at "National Science Review"
DOI: 10.1093/nsr/nwaf022
Abstract: ABSTRACT Inter-organelle communication coordinates cellular homeostasis and function. Juvenile hormone (JH) is produced in the corpora allata (CA) and acts as a gonadotrophic hormone in most insects. Using transcriptomic, biochemical, molecular, and genetic analyses, here… read more here.
Keywords: biosynthesis; hormone; organelle communication; inter organelle ... See more keywords
Organelle stress and alterations in inter-organelle crosstalk during liver fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000012
Abstract: The synchronous functioning and quality control of organelles ensure cell survival and function and are essential for maintaining homeostasis. Prolonged exposure to stressors (viruses, bacteria, parasitic infection, alcohol, drug) or genetic mutations often disrupt the… read more here.
Keywords: organelle crosstalk; liver fibrosis; organelle stress; fibrosis ... See more keywords
Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a041261
Abstract: The endoplasmic reticulum (ER) is a key organelle involved in the regulation of lipid and glucose metabolism, proteostasis, Ca2+ signaling, and detoxification. The structural organization of the ER is very dynamic and complex, with distinct… read more here.
Keywords: endoplasmic reticulum; architecture inter; disease; reticulum architecture ... See more keywords