Single Image Capture of Bioactive Ion Crosstalk within Inter‐Organelle Membrane Contacts at Nanometer Resolution
Sign Up to like & getrecommendations! Published in 2022 at "Small Methods"
DOI: 10.1002/smtd.202200321
Abstract: Rapid bioactive ion exchange is a form of communication that regulates a wide range of biological processes. Despite advances in super‐resolution optical microscopy, visualizing ion exchange remains challenging due to the extremely fast nature of… read more here.
Keywords: nanometer resolution; inter organelle; bioactive ion; ion ... See more keywords
Organelle homeostasis principles: How organelle quality control and inter-organelle crosstalk promote cell survival.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.03.012
Abstract: To survive, cells sense their surroundings and adapt to enable homeostasis. Studies dissecting this process reveal organizational principles, including quality-control pathways, changes to organelle shape, and inter-organelle communication, that facilitate metabolic or developmental remodeling. In… read more here.
Keywords: homeostasis; organelle homeostasis; homeostasis principles; inter organelle ... See more keywords
Alterations in Inter-organelle Crosstalk and Ca2+ Signaling through Mitochondria during Proteotoxic Stresses.
Sign Up to like & getrecommendations! Published in 2020 at "Mitochondrion"
DOI: 10.1016/j.mito.2020.12.003
Abstract: BACKGROUND Biogenesis and function of mitochondria is profoundly dependent on cytosolic translation of mitochondrial pre-proteins and its subsequent translocation and folding inside the organelle. Continuous exposure of non-native precursor proteins, exposure to damaging by-products of… read more here.
Keywords: alterations inter; ca2 signaling; mitochondrial proteotoxicity; ca2 ... See more keywords
Organelle Transporters and Inter-Organelle Communication as Drivers of Metabolic Regulation and Cellular Homeostasis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular metabolism"
DOI: 10.1016/j.molmet.2022.101481
Abstract: Spatial compartmentalization of metabolic pathways within membrane-separated organelles is key to the ability of eukaryotic cells to precisely regulate their biochemical functions. Membrane-bound organelles such as mitochondria, endoplasmic reticulum (ER) and lysosomes enable the concentration… read more here.
Keywords: communication drivers; communication; organelle communication; organelle transporters ... See more keywords
Inter-Organelle Contact Sites Mediate the Intracellular Antioxidant Activity of Platinum Nanozymes: A New Perspective on Cell–Nanoparticle Interaction and Signaling
Sign Up to like & getrecommendations! Published in 2023 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.2c22375
Abstract: The catalytic and antioxidant properties of platinum nanoparticles (PtNPs) make them promising candidates for several applications in nanomedicine. However, an open issue, still shared among most nanomaterials, is the understanding on how internalized PtNPs, which… read more here.
Keywords: ptnps; cell; contact sites; inter organelle ... See more keywords
Fundamental roles for inter-organelle communication in aging
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20220519
Abstract: Advances in public health have nearly doubled life expectancy over the last century, but this demographic shift has also changed the landscape of human illness. Today, chronic and age-dependent diseases dominate the leading causes of… read more here.
Keywords: organelle interactions; roles inter; inter organelle; organelle communication ... See more keywords
Organelle stress and alterations in inter-organelle crosstalk during liver fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000012
Abstract: The synchronous functioning and quality control of organelles ensure cell survival and function and are essential for maintaining homeostasis. Prolonged exposure to stressors (viruses, bacteria, parasitic infection, alcohol, drug) or genetic mutations often disrupt the… read more here.
Keywords: organelle crosstalk; liver fibrosis; organelle stress; fibrosis ... See more keywords
Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a041261
Abstract: The endoplasmic reticulum (ER) is a key organelle involved in the regulation of lipid and glucose metabolism, proteostasis, Ca2+ signaling, and detoxification. The structural organization of the ER is very dynamic and complex, with distinct… read more here.
Keywords: endoplasmic reticulum; architecture inter; disease; reticulum architecture ... See more keywords
Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf0138
Abstract: Proliferating cells rely on acetyl-CoA to support membrane biogenesis and acetylation. Several organelle-specific pathways are available for provision of acetyl-CoA as nutrient availability fluctuates, so understanding how cells maintain acetyl-CoA flux under such stresses is… read more here.
Keywords: acetyl coa; organelle cross; coa; lipogenesis ... See more keywords
Crucial Players for Inter-Organelle Communication: PI5P4Ks and Their Lipid Product PI-4,5-P2 Come to the Surface
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.791758
Abstract: While organelles are individual compartments with specialized functions, it is becoming clear that organellar communication is essential for maintaining cellular homeostasis. This cooperation is carried out by various interactions taking place on the membranes of… read more here.
Keywords: product; communication; organelle communication; players inter ... See more keywords
Luteinizing Hormone Regulation of Inter-Organelle Communication and Fate of the Corpus Luteum
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22189972
Abstract: The corpus luteum is an endocrine gland that synthesizes the steroid hormone progesterone. luteinizing hormone (LH) is a key luteotropic hormone that stimulates ovulation, luteal development, progesterone biosynthesis, and maintenance of the corpus luteum. Luteotropic… read more here.
Keywords: inter organelle; hormone; corpus luteum; luteinizing hormone ... See more keywords