Inter-phenotypic differences in CYP2C9 and CYP2C19 metabolism: Bayesian meta-regression of human population variability in kinetics and application in chemical risk assessment.
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DOI: 10.1016/j.toxlet.2020.11.016
Abstract: Quantifying variability in pharmacokinetics (PK) and toxicokinetics (TK) provides a science-based approach to refine uncertainty factors (UFs) for chemical risk assessment. In this context, genetic polymorphisms in cytochromes P450 (CYPs) drive inter-phenotypic differences and may… read more here.
Keywords: inter phenotypic; metabolism; variability; cyp2c9 cyp2c19 ... See more keywords