Traf2- and Nck-interacting kinase inhibitors: a patent review (2008–2024)
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DOI: 10.1080/13543776.2025.2548585
Abstract: ABSTRACT Introduction Traf2- and Nck-interacting kinase (TNIK) is a crucial player in various intracellular signaling pathways, including Wnt/β-catenin, cytoskeleton organization, and immune activation. It phosphorylates several key target genes and is widely expressed in different… read more here.
Keywords: oncology; nck interacting; 2008 2024; interacting kinase ... See more keywords
MAPK-interacting kinase 1 (Mnk1) regulates platelet production, activation, and thrombosis.
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DOI: 10.1182/blood.2022015568
Abstract: The MAPK-interacting kinase (Mnk) family includes Mnk1 and Mnk2, which are phosphorylated and activated in response to extracellular stimuli. Mnk1 contributes to cellular responses by regulating mRNA translation and mRNA translation influences platelet production and… read more here.
Keywords: mnk1 regulates; mnk1; interacting kinase; mapk interacting ... See more keywords
Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma
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DOI: 10.3390/cancers12051258
Abstract: Background: The treatment of patients with metastatic synovial sarcoma is still challenging, and the development of new molecular therapeutics is desirable. Dysregulation of Wnt signaling has been implicated in synovial sarcoma. Traf2-and-Nck-interacting kinase (TNIK) is… read more here.
Keywords: sarcoma; tnik; nck interacting; synovial sarcoma ... See more keywords