Exploring Thioredoxin‐Interacting Protein (TXNIP) as a Therapeutic Target for Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2025 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.70082
Abstract: Cardiovascular diseases (CVDs) are the primary causes of death globally. Risk factors such as aging, poor lifestyle, and genetics significantly influence how these diseases progress, with oxidative stress being an important factor in their pathogenesis.… read more here.
Keywords: therapeutic target; txnip; cardiovascular diseases; interacting protein ... See more keywords
Ermin is a p116RIP‐interacting protein promoting oligodendroglial differentiation and myelin maintenance
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DOI: 10.1002/glia.23838
Abstract: Myelin sheaths, which insulate the axons and ensure saltatory conduction of the nerve impulse, are generated and maintained via largely uncharacterized mechanisms. Ermin is an oligodendrocyte‐specific protein associated with the cytoskeleton, but how it regulates… read more here.
Keywords: oligodendroglial differentiation; differentiation; myelin maintenance; interacting protein ... See more keywords
TNFAIP3 Interacting Protein 3 Is an Activator of Hippo‐YAP Signaling Protecting Against Hepatic Ischemia/Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32015
Abstract: Hepatic ischemia/reperfusion (I/R) injury, a common clinical problem that occurs during liver surgical procedures, causes a large proportion of early graft failure and organ rejection cases. The identification of key regulators of hepatic I/R injury… read more here.
Keywords: interacting protein; ischemia reperfusion; reperfusion injury; injury ... See more keywords
Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-017-1103-4
Abstract: BackgroundThe redox regulatory protein, thioredoxin-interacting protein (TXNIP), has been confirmed as an important tumor suppressor gene in various types of human cancers. In previous studies, we found that overexpression of tumor suppressor gene RIZ1 in… read more here.
Keywords: recurrence; expression txnip; thioredoxin interacting; expression ... See more keywords
Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice
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DOI: 10.1007/s11427-018-9336-6
Abstract: Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the carcinogenesis of mammary gland is available. We established a Kindlin-2 transgenic mouse model using… read more here.
Keywords: integrin interacting; transgenic mice; mammary gland; interacting protein ... See more keywords
Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0917-z
Abstract: Neurological diseases, including acute attacks (e.g., ischemic stroke) and chronic neurodegenerative diseases (e.g., Alzheimer’s disease), have always been one of the leading cause of morbidity and mortality worldwide. These debilitating diseases represent an enormous disease… read more here.
Keywords: protein; neurodegenerative diseases; pathology; thioredoxin interacting ... See more keywords
Resonance assignments of the human receptor interacting protein kinase 1 (RIPK1) in its fibrillar conformation
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DOI: 10.1007/s12104-025-10249-y
Abstract: Receptor-interacting protein kinase 1 (RIPK1) is a key regulator of necroptotic signalling that forms functional amyloid fibrils through its RIP Homotypic Interaction Motif (RHIM). Here, we report the solid-state NMR chemical shift assignments for the… read more here.
Keywords: protein kinase; ripk1; receptor interacting; interacting protein ... See more keywords
Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.08.114
Abstract: Thioredoxin-interacting protein (TXNIP) has multiple disease-associated functions including inducing oxidative stress by inhibiting the anti-oxidant and thiol reducing activity of thioredoxin (TRX), reducing cellular glucose transport, and is a component of the activated inflammasome complex.… read more here.
Keywords: thioredoxin interacting; thioredoxin; expression; interacting protein ... See more keywords
Immune modulating effects of receptor interacting protein 2 (RIP2) in autoinflammation and immunity.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical immunology"
DOI: 10.1016/j.clim.2020.108648
Abstract: Receptor-interacting protein 2 (RIP2) is a kinase that is involved in downstream signaling of nuclear oligomerization domain (NOD)-like receptors NOD1 and 2 sensing bacterial peptidoglycans. RIP2-deficiency or targeting of RIP2 by pharmaceutical inhibitors partially ameliorates… read more here.
Keywords: receptor interacting; interacting protein; autoinflammation immunity; protein rip2 ... See more keywords
Identification and characterization of a DevR-interacting protein in Aspergillus oryzae.
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DOI: 10.1016/j.funbio.2020.01.001
Abstract: The basic helix-loop-helix (bHLH) proteins belong to a superfamily of transcription factors. Recent research has shown that the bHLH transcription factor DevR is involved in both sexual and asexual development as well as conidial melanin… read more here.
Keywords: characterization devr; devr interacting; devr; interacting protein ... See more keywords
Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation.
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DOI: 10.1021/acs.biochem.7b00776
Abstract: Protein misfolding due to mutation(s) and/or generation of unstable intermediate state(s) can be the cause of aberrant aggregations, leading to cellular degeneration. While molecular signatures like amyloidogenic regions cause aggregation, other features in proteins, like… read more here.
Keywords: protein; aggregation; disordered nanostructure; huntingtin interacting ... See more keywords