The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis.
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DOI: 10.1182/blood-2017-11-815035
Abstract: Eleven-nineteen leukemia (ENL) is a chromatin reader present in complexes stimulating transcriptional elongation. It is fused to mixed-lineage leukemia (MLL) in leukemia, and missense mutations have been identified in Wilms tumor and acute myeloid leukemia.… read more here.
Keywords: polycomb silencing; paf1; leukemia; interaction enl ... See more keywords