Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors.
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DOI: 10.1021/acschembio.2c00177
Abstract: The main challenge in inhibiting protein-protein interactions (PPI) for therapeutic purposes is designing molecules that bind specifically to the interaction hotspots. Adding to the complexity, such hotspots can be within both structured and disordered interaction… read more here.
Keywords: interaction; structured disordered; interaction hotspots; peptide inhibitors ... See more keywords
Promiscuous Ligands from Experimentally Determined Structures, Binding Conformations, and Protein Family-Dependent Interaction Hotspots
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DOI: 10.1021/acsomega.8b03481
Abstract: Compound promiscuity is often attributed to nonspecific binding or assay artifacts. On the other hand, it is well-known that many pharmaceutically relevant compounds are capable of engaging multiple targets in vivo, giving rise to polypharmacology.… read more here.
Keywords: promiscuous ligands; promiscuous binding; binding conformations; interaction hotspots ... See more keywords