Visualizing the Residue Interaction Landscape of Proteins by Temporal Network Embedding
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Chemical Theory and Computation"
DOI: 10.1021/acs.jctc.2c01228
Abstract: Characterizing the structural dynamics of proteins with heterogeneous conformational landscapes is crucial to understanding complex biomolecular processes. To this end, dimensionality reduction algorithms are used to produce low-dimensional embeddings of the high-dimensional conformational phase space.… read more here.
Keywords: interaction; network; interaction landscape; residue interaction ... See more keywords
Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-16-1045
Abstract: Recent studies have characterized the extensive somatic alterations that arise during cancer. However, the somatic evolution of a tumor may be significantly affected by inherited polymorphisms carried in the germline. Here, we analyze genomic data… read more here.
Keywords: cancer genes; interaction landscape; somatic events; inherited polymorphisms ... See more keywords