Functional Interaction Network Construction and Analysis for Disease Discovery.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6783-4_11
Abstract: Network-based approaches project seemingly unrelated genes or proteins onto a large-scale network context, therefore providing a holistic visualization and analysis platform for genomic data generated from high-throughput experiments, reducing the dimensionality of data via using… read more here.
Keywords: interaction network; network; analysis; network construction ... See more keywords
Probing the functions of long non-coding RNAs by exploiting the topology of global association and interaction network
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.03.017
Abstract: Long non-coding RNAs (lncRNAs) are involved in many biological processes, such as immune response, development, differentiation and gene imprinting and are associated with diseases and cancers. But the functions of the vast majority of lncRNAs… read more here.
Keywords: interaction network; network; coding rnas; long non ... See more keywords
The USP7 protein interaction network and its roles in tumorigenesis
Sign Up to like & getrecommendations! Published in 2020 at "Genes and Diseases"
DOI: 10.1016/j.gendis.2020.10.004
Abstract: Abstract Ubiquitin-specific protease (USP7), also known as Herpesvirus-associated ubiquitin-specific protease (HAUSP), is a deubiquitinase. There has been significant recent attention on USP7 following the discovery that USP7 is a key regulator of the p53-MDM2 pathway.… read more here.
Keywords: protein; interaction network; protein interaction; usp7 protein ... See more keywords
Spatial-interaction network analysis of built environmental influence on daily public transport demand
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Transport Geography"
DOI: 10.1016/j.jtrangeo.2021.102991
Abstract: Abstract Many studies have evaluated the influence of the built environment on public transport. Some studies assign subjective weights to environmental factors, which could oversimplify spatial heterogeneity and overlook the temporal dimension. On the other… read more here.
Keywords: public transport; spatial interaction; interaction network; transport ... See more keywords
The regulation of the protein interaction network by monoubiquitination.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2022.102333
Abstract: The conjugation of a single ubiquitin or monoubiquitination acts as a versatile signal that can have both degradative and non-degradative functions. The latter is of particular interest as emerging evidence indicates that ubiquitin-driven alterations of… read more here.
Keywords: interaction network; regulation protein; interaction; network monoubiquitination ... See more keywords
Machine Learning Approach to Community Detection in a High-Entropy Alloy Interaction Network
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00317
Abstract: There is a growing trend toward the use of interaction network methods and algorithms, including community-based detection methods, in various fields of science. The approach is already used in many applications, for example, in social… read more here.
Keywords: community; community detection; alloy; interaction network ... See more keywords
Identification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17330-0
Abstract: Understanding the biological factors that are characteristic of metastasis in melanoma remains a key approach to improving treatment. In this study, we seek to identify a gene signature of metastatic melanoma. We configured a new… read more here.
Keywords: melanoma; interaction network; network; metastatic primary ... See more keywords
An interaction network driven approach for identifying biomarkers for progressing cervical intraepithelial neoplasia
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31187-x
Abstract: Overlapping genes across high-grade squamous intraepithelial lesions (CIN2 and 3) and cancer may serve as potential biomarkers for this progressive disease. Differentially expressed genes (DEGs) of dysplastic (CIN2 and CIN3) and cancer cells were identified… read more here.
Keywords: cancer; interaction network; zwint cdc7; progressing cervical ... See more keywords
Multi-omics Data Integration by Generative Adversarial Network.
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab608
Abstract: MOTIVATION Accurate disease phenotype prediction plays an important role in the treatment of heterogeneous diseases like cancer in the era of precision medicine. With the advent of high throughput technologies, more comprehensive multi-omics data is… read more here.
Keywords: interaction network; multi omics; network; omics data ... See more keywords
Clustering Sparse Data With Feature Correlation With Application to Discover Subtypes in Cancer
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Access"
DOI: 10.1109/access.2020.2982569
Abstract: In this paper, given data with high-dimensional features, we study this problem of how to calculate the similarity between two samples by considering feature interaction network, where a feature interaction network represents the relationship between… read more here.
Keywords: similarity; cancer; feature; network ... See more keywords
Hyperspectral and Multispectral Classification for Coastal Wetland Using Depthwise Feature Interaction Network
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Geoscience and Remote Sensing"
DOI: 10.1109/tgrs.2021.3097093
Abstract: The monitoring of coastal wetlands is of great importance to the protection of marine and terrestrial ecosystems. However, due to the complex environment, severe vegetation mixture, and difficulty of access, it is impossible to accurately… read more here.
Keywords: feature interaction; wetland; classification; feature ... See more keywords