Evaluation of Drug-Drug Interaction Potential of Enarodustat (JTZ-951) Using a Cytochrome P450 Probe Cocktail.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1263
Abstract: The drug interaction potential of enarodustat (doses: 25, 50 mg) on the activity of cytochrome P450 (CYP) 1A2, 2C9, 2C19, 2D6, and 3A4 was evaluated after once-daily administration for 15 days in a phase 1 multiple-ascending-dose… read more here.
Keywords: interaction potential; day; enarodustat; drug interaction ... See more keywords
Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2891
Abstract: Oral formulations prepared from the leaves of the kratom (Mitragyna speciosa) plant are increasingly used for their opioid‐like effects to self‐manage opioid withdrawal and pain. Calls to US poison centers involving kratom exposures increased >50‐fold… read more here.
Keywords: interaction potential; kratom; drug interaction; natural product ... See more keywords
Metabolite profiling and evaluation of CYP450 interaction potential of 'Trimada'- An Ayurvedic formulation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113457
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Trimada is well-known polyherbal Ayurvedic formulation used in Indian Traditional medicine since ancient times. It consisted of three inebriant herbs including "Chitraka" (Plumbago zeylanica Linn. Family- Plumabaginaceae), "Musta" (Cyperus rotundus Linn. Family- Cyperaceae)… read more here.
Keywords: interaction potential; individual herbs; trimada; formulation ... See more keywords
On the analytic smoothing effect for the Hartree equation with a short range interaction potential
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Mathematical Analysis and Applications"
DOI: 10.1016/j.jmaa.2017.05.067
Abstract: Abstract We consider the Cauchy problem for the Hartree equation in space dimension d ≥ 2 . We assume that the interaction potential V ( x ) is short range. More precisely, we consider the… read more here.
Keywords: interaction potential; short range; hartree equation; space ... See more keywords
Unveiling the Interaction Potential Surface between Drug-Entrapped Polymeric Micelles Clarifying the High Drug Nanocarrier Efficiency.
Sign Up to like & getrecommendations! Published in 2021 at "Nano letters"
DOI: 10.1021/acs.nanolett.0c03978
Abstract: Polymeric micelles are invaluable media as drug nanocarriers. Although knowledge of an interaction between the micelles is a key to understanding the mechanisms and developing the superior functions, the interaction potential surface between drug-incorporated polymeric… read more here.
Keywords: potential surface; interaction potential; surface drug; drug ... See more keywords
Geometric description of self-interaction potential in symmetric protein complexes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Data"
DOI: 10.1038/s41597-019-0058-x
Abstract: Proteins can self-associate with copies of themselves to form symmetric complexes called homomers. Homomers are widespread in all kingdoms of life and allow for unique geometric and functional properties, as reflected in viral capsids or… read more here.
Keywords: protein; potential symmetric; description self; interaction potential ... See more keywords
Strong effect of the interaction potential cut-off on the crystallinity of films grown by simulations
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Simulation"
DOI: 10.1080/08927022.2017.1319056
Abstract: Abstract The paper deals with the methodology of film growth simulations using classical molecular dynamics and an empirical interaction potential. We focus on the effect of the cut-off distance (rC) of the short-range part of… read more here.
Keywords: effect; crystallinity; interaction potential; cut ... See more keywords
Assessment of Herb-Drug Interaction Potential of Five Common Species of Licorice and Their Phytochemical Constituents.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of dietary supplements"
DOI: 10.1080/19390211.2022.2050875
Abstract: Abstract The dried roots and rhizomes of Glycyrrhiza species (G. glabra, G. uralensis and G. inflata), commonly known as licorice, have long been used in traditional medicine. In addition, two other species, G. echinata and… read more here.
Keywords: interaction potential; activity; herb drug; drug interaction ... See more keywords
Evaluation of drug interaction potential of zanubrutinib with cocktail probes representative of CYP3A4, CYP2C9, CYP2C19, P‐gp and BCRP
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.14707
Abstract: This study aims to assess the potential effects of zanubrutinib on the activity of cytochrome P450 (CYP) enzymes and drug transporter proteins using a cocktail probe approach. read more here.
Keywords: drug interaction; evaluation drug; interaction potential; drug ... See more keywords
Shifts in phenological distributions reshape interaction potential in natural communities.
Sign Up to like & getrecommendations! Published in 2018 at "Ecology letters"
DOI: 10.1111/ele.13081
Abstract: Climate change has changed the phenologies of species worldwide, but it remains unclear how these phenological changes will affect species interactions and the structure of natural communities. Using a novel approach to analyse long-term data… read more here.
Keywords: interaction potential; natural communities; phenological shifts; phenological distributions ... See more keywords
Evaluation of Clinical Drug Interaction Potential of Clofazimine Using Static and Dynamic Modeling Approaches
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.117.077834
Abstract: The 2016 World Health Organization treatment recommendations for drug-resistant tuberculosis (DR-TB) positioned clofazimine as a core second-line drug. Being identified as a cytochrome P450 (P450) inhibitor in vitro, a P450-mediated drug interaction may be likely… read more here.
Keywords: drug interaction; interaction potential; drug; potential clofazimine ... See more keywords