Non‐homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201600209
Abstract: Non‐homologous end‐joining (NHEJ) is the dominant means of repairing chromosomal DNA double strand breaks (DSBs), and is essential in human cells. Fifteen or more proteins can be involved in the detection, signalling, synapsis, end‐processing and… read more here.
Keywords: end joining; end; homologous end; interaction ... See more keywords
Predicting protein–protein interaction sites using modified support vector machine
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Machine Learning and Cybernetics"
DOI: 10.1007/s13042-015-0450-6
Abstract: Protein–protein interaction plays a fundamental role in many biological processes and diseases. Characterizing protein interaction sites is crucial for the understanding of the mechanism of protein–protein interaction and their cellular functions. In this paper, we… read more here.
Keywords: protein interaction; machine; protein protein; interaction ... See more keywords
Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.10.002
Abstract: Summary Cell migration often involves the formation of sheet-like lamellipodia generated by branched actin filaments. The branches are initiated when Arp2/3 complex [1] is activated by WAVE regulatory complex (WRC) downstream of small GTPases of… read more here.
Keywords: wave regulatory; regulatory complex; site; wrc ... See more keywords
Interaction sites of PEF proteins for recognition of their targets.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.04.097
Abstract: The EF-hand is a helix-loop-helix motif observed mainly in intracellular calcium binding proteins. The EF-hand usually occurs as a pair, EF-lobe, which is a unit of evolution and structure. Penta EF-hand (PEF) proteins form a… read more here.
Keywords: pef; sites pef; hand; pef proteins ... See more keywords
Identification and molecular analysis of interaction sites in the MtSEO-F1 protein involved in forisome assembly.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.12.092
Abstract: Forisomes are large mechanoprotein complexes found solely in legumes such as Medicago truncatula. They comprise several "sieve element occlusion by forisome" (SEO-F) subunits, with MtSEO-F1 as the major structure-forming component. SEO-F proteins possess three conserved… read more here.
Keywords: forisome assembly; dimerization; analysis; mtseo protein ... See more keywords
Residue co-evolution helps predict interaction sites in α-helical membrane proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2019.02.009
Abstract: Many integral membrane proteins, just like their globular counterparts, form either transient or permanent multi-subunit complexes to fulfill specific cellular roles. Although numerous interactions between these proteins have been experientially determined, the structural coverage of… read more here.
Keywords: membrane proteins; interaction; interaction sites; membrane ... See more keywords
Simultaneous Prediction of Interaction Sites on the Protein and Peptide Sides of Complexes through Multilayer Graph Convolutional Networks
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00192
Abstract: Identifying the binding residues of protein-peptide complexes is essential for understanding protein function mechanisms and exploring drug discovery. Recently, many computational methods have been developed to predict the interaction sites of either protein or peptide.… read more here.
Keywords: protein peptide; sites protein; interaction sites; peptide sides ... See more keywords
Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01165
Abstract: The identification of starting points for compound development is one of the key steps in early-stage drug discovery. Information-rich techniques such as crystallographic fragment screening can potentially increase the efficiency of this step by providing… read more here.
Keywords: protein protein; interaction sites; fragment screening; crystallographic fragment ... See more keywords
Isolated π-Interaction Sites in Mesoporous MOF Backbone for Repetitive and Reversible Dynamics in Water.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b19211
Abstract: We report the introduction of π-interaction sites into a series of chemically robust metal-organic frameworks (MOFs), MOF-526, -527, and -528, with progressively increased pore size, 1.9-3.7 nm, and the inclusion and release of large organic… read more here.
Keywords: water; repetitive reversible; interaction; interaction sites ... See more keywords
Synergistic and Competitive Lipid Interactions in the Serotonin1A Receptor Microenvironment.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00422
Abstract: The interaction of lipids with G-protein-coupled receptors (GPCRs) has been shown to modulate and dictate several aspects of GPCR organization and function. Diverse lipid interaction sites have been identified from structural biology, bioinformatics, and molecular… read more here.
Keywords: serotonin1a receptor; interaction sites; lipid interactions; cholesterol ... See more keywords
Electrolyte solutions at heterogeneously charged substrates.
Sign Up to like & getrecommendations! Published in 2018 at "Soft matter"
DOI: 10.1039/c8sm00497h
Abstract: The influence of a chemically or electrically heterogeneous distribution of interaction sites at a planar substrate on the number density of an adjacent fluid is studied by means of classical density functional theory (DFT). In… read more here.
Keywords: heterogeneously charged; electrolyte solutions; interaction; interaction sites ... See more keywords