Order and interactions in DNA arrays: Multiscale molecular dynamics simulation
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05109-2
Abstract: While densely packed DNA arrays are known to exhibit hexagonal and orthorhombic local packings, the detailed mechanism governing the associated phase transition remains rather elusive. Furthermore, at high densities the atomistic resolution is paramount to… read more here.
Keywords: order interactions; dna arrays; dna; simulation ... See more keywords
Exploring the interactions of a DNA aptamer with human serum albumins: simulation studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2016.1224733
Abstract: The level of blood glucose is a traditional indicator for diabetes diagnosis and treatment. To track diabetes progression, the levels of blood sugar and the percentage of glycated hemoglobin (HbA1c... read more here.
Keywords: aptamer human; human serum; exploring interactions; dna aptamer ... See more keywords
Synergistic Interactions Between DNA and Actin Trigger Emergent Viscoelastic Behavior.
Sign Up to like & getrecommendations! Published in 2018 at "Physical review letters"
DOI: 10.1103/physrevlett.121.257801
Abstract: Composites of flexible and rigid polymers are ubiquitous in biology and industry alike, yet the physical principles determining their mechanical properties are far from understood. Here, we couple force spectroscopy with large-scale Brownian dynamics simulations… read more here.
Keywords: emergent viscoelastic; synergistic interactions; trigger emergent; interactions dna ... See more keywords
DNA binding alters ARv7 dimer interactions.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.258332
Abstract: Androgen receptor (AR) splice variants are described as one of the potential drivers of lethal castration-resistant prostate cancer. Androgen receptor splice variant 7 (ARv7) is the most commonly observed isoform and strongly correlates with resistance… read more here.
Keywords: binding alters; alters arv7; dna binding; arv7 dimer ... See more keywords
Copper (I)-Chloroquine Complexes: Interactions with DNA and Ferriprotoporphyrin, Inhibition of β-Hematin Formation and Relation to Antimalarial Activity
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15080921
Abstract: A new Cu(I)-chloroquine (CQ) complex [Cu(CQ)(PPh3)2]NO3 (1) was synthesized and characterized, and its mechanism of action studied concomitant with the previously reported complex [Cu(CQ)2]Cl (2). These copper (I) coordination compounds can be considered as potential… read more here.
Keywords: inhibition; copper; interactions dna; chloroquine ... See more keywords