Predicting drug-target interactions from drug structure and protein sequence using novel convolutional neural networks
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DOI: 10.1186/s12859-019-3263-x
Abstract: Accurate identification of potential interactions between drugs and protein targets is a critical step to accelerate drug discovery. Despite many relative experimental researches have been done in the past decades, detecting drug-target interactions (DTIs) remains… read more here.
Keywords: predicting drug; drug; drug target; interactions drug ... See more keywords
Using the Cyclotide Scaffold for Targeting Biomolecular Interactions in Drug Development
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DOI: 10.3390/molecules27196430
Abstract: This review provides an overview of the properties of cyclotides and their potential for developing novel peptide-based therapeutics. The selective disruption of protein–protein interactions remains challenging, as the interacting surfaces are relatively large and flat.… read more here.
Keywords: interactions drug; biomolecular interactions; scaffold targeting; using cyclotide ... See more keywords