A Split Renilla Luciferase Complementation Assay for the Evaluation of Hsp90/Aha1 Complex Disruptors and Their Activity at the Aha1 C-Terminal Domain.
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DOI: 10.1021/acschembio.2c00854
Abstract: Disruption of interactions between Hsp90 and the cochaperone protein, Aha1, has emerged as a therapeutic strategy to inhibit Aha1-driven cancer metastasis and tau aggregation in models of tauopathy. A combination of split Renilla luciferase assays… read more here.
Keywords: interactions hsp90; split renilla; aha1; renilla luciferase ... See more keywords