Chemogenetic interactions in human cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2019.09.006
Abstract: Chemogenetic profiling enables the identification of genes that enhance or suppress the phenotypic effect of chemical compounds. Using this approach in cancer therapies could improve our ability to predict the response of specific tumor genotypes… read more here.
Keywords: chemogenetic interactions; human cancer; drug; interactions human ... See more keywords
CITEdb: a manually curated database of cell–cell interactions in human
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac654
Abstract: Abstract Motivation The interactions among various types of cells play critical roles in cell functions and the maintenance of the entire organism. While cell–cell interactions are traditionally revealed from experimental studies, recent developments in single-cell… read more here.
Keywords: cell; database; interactions human; citedb ... See more keywords
Thalamic regulation of frontal interactions in human cognitive flexibility
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1010500
Abstract: Interactions across frontal cortex are critical for cognition. Animal studies suggest a role for mediodorsal thalamus (MD) in these interactions, but the computations performed and direct relevance to human decision making are unclear. Here, inspired… read more here.
Keywords: dlpfc; regulation frontal; interactions human; frontal interactions ... See more keywords
Modeling and Targeting Neuroglial Interactions with Human Pluripotent Stem Cell Models
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031684
Abstract: Generation of relevant and robust models for neurological disorders is of main importance for both target identification and drug discovery. The non-cell autonomous effects of glial cells on neurons have been described in a broad… read more here.
Keywords: pluripotent stem; interactions human; targeting neuroglial; modeling targeting ... See more keywords
Neurotrophins: Neuroimmune Interactions in Human Atopic Diseases
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076105
Abstract: Allergic diseases are accompanied by a variety of symptoms such as pruritus, coughing, sneezing, and watery eyes, which can result in severe physiological and even psychological impairments. The exact mechanisms of these conditions are not… read more here.
Keywords: human atopic; neurotrophins neuroimmune; interactions human; atopic diseases ... See more keywords
Fungal Colonization and Infections—Interactions with Other Human Diseases
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DOI: 10.3390/pathogens11020212
Abstract: Candida albicans is a commensal fungus that asymptomatically colonizes the skin and mucosa of 60% of healthy individuals. Breaches in the cutaneous and mucosal barriers trigger candidiasis that ranges from asymptomatic candidemia and mucosal infections… read more here.
Keywords: diseases fungal; infections interactions; interactions human; human diseases ... See more keywords