Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12214-9
Abstract: In eukaryotes, several “hub” proteins integrate signals from different interacting partners that bind through intrinsically disordered regions. The 14-3-3 protein hub, which plays wide-ranging roles in cellular processes, has been linked to numerous human disorders… read more here.
Keywords: proteins unraveling; chimeric proteins; disordered partners; unraveling interactions ... See more keywords
NMR insights into dynamic, multivalent interactions of intrinsically disordered regions: from discrete complexes to condensates
Sign Up to like & getrecommendations! Published in 2022 at "Essays in Biochemistry"
DOI: 10.1042/ebc20220056
Abstract: Abstract The spatial and temporal organization of interactions between proteins underlie the regulation of most cellular processes. The requirement for such interactions to be specific predisposes a view that protein–protein interactions are relatively static and… read more here.
Keywords: nmr insights; interactions intrinsically; intrinsically disordered; multivalent interactions ... See more keywords