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Published in 2022 at "Annual review of biochemistry"
DOI: 10.1146/annurev-biochem-040320-104151
Abstract: The cellular interior is composed of a variety of microenvironments defined by distinct local compositions and composition-dependent intermolecular interactions. We review the various types of nonspecific interactions between proteins and between proteins and other macromolecules…
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Keywords:
influence nonspecific;
nonspecific interactions;
protein associations;
interactions protein ... See more keywords
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1
Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1012507
Abstract: The identification and optimization of promising lead molecules is essential for drug discovery. Recently, artificial intelligence (AI) based generative methods provided complementary approaches for generating molecules under specific design constraints of relevance in drug design.…
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Keywords:
protein binding;
design;
interactions protein;
optimizing interactions ... See more keywords
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Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2018-0312
Abstract: In this review, we report NMR studies of ligand-GPCR interactions, including both ligand-observed and protein-observed NMR experiments. Published studies exemplify how NMR can be used as a powerful tool to design novel GPCR ligands and…
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Keywords:
protein coupled;
ligand interactions;
investigation protein;
protein ligand ... See more keywords