Metal interactions of α-synuclein probed by NMR amide-proton exchange
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1167766
Abstract: The aberrant aggregation of α-synuclein (αS), a disordered protein primarily expressed in neuronal cells, is strongly associated with the underlying mechanisms of Parkinson’s disease. It is now established that αS has a weak affinity for… read more here.
Keywords: proton exchange; metal interactions; exchange; interactions synuclein ... See more keywords
Modulation of the Interactions Between α-Synuclein and Lipid Membranes by Post-translational Modifications
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.661117
Abstract: Parkinson's disease is characterised by the presence in brain tissue of aberrant inclusions known as Lewy bodies and Lewy neurites, which are deposits composed by α-synuclein and a variety of other cellular components, including in… read more here.
Keywords: lipid membranes; interactions synuclein; post translational; modulation interactions ... See more keywords
Morphology-Dependent Interactions between α-Synuclein Monomers and Fibrils
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065191
Abstract: Amyloid fibrils may adopt different morphologies depending on the solution conditions and the protein sequence. Here, we show that two chemically identical but morphologically distinct α-synuclein fibrils can form under identical conditions. This was observed… read more here.
Keywords: fibrils morphology; morphology; dependent interactions; interactions synuclein ... See more keywords