&agr;-Ketoglutarate drives electroneutral NaCl reabsorption in intercalated cells by activating a G-protein coupled receptor, Oxgr1
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DOI: 10.1097/mnh.0000000000000353
Abstract: Purpose of review This review describes the recent discoveries about a powerful electroneutral NaCl reabsorption mechanism in intercalated cells, and its regulation by an intrarenal metabolite paracrine, &agr;-ketoglutartate, and the G-protein coupled receptor, Oxgr1. Recent… read more here.
Keywords: protein; electroneutral nacl; reabsorption; intercalated cells ... See more keywords
Loss of Ncoa7 leads to oxidative stress in kidney intercalated cells
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DOI: 10.1152/physiol.2023.38.s1.5732491
Abstract: Oxidative stress (OS) results from excessive production of reactive oxygen species, relative to endogenous antioxidant defenses, leading to cellular damage. The metabolically active kidney is vulnerable to OS, which is a key step in the… read more here.
Keywords: loss ncoa7; kidney; oxidative stress; physiology ... See more keywords
Regulation of Blood Pressure and Salt Balance By Pendrin-Positive Intercalated Cells: Donald Seldin Lecture 2020
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DOI: 10.1161/hypertensionaha.121.16492
Abstract: Intercalated cells make up about a third of all cells within the connecting tubule and the collecting duct and are subclassified as type A, type B and non-A, non-B based on the subcellular distribution of… read more here.
Keywords: pendrin positive; pendrin; aldosterone; intercalated cells ... See more keywords
Modus operandi of ClC-K2 Cl− Channel in the Collecting Duct Intercalated Cells
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DOI: 10.3390/biom13010177
Abstract: The renal collecting duct is known to play a critical role in many physiological processes, including systemic water–electrolyte homeostasis, acid–base balance, and the salt sensitivity of blood pressure. ClC-K2 (ClC-Kb in humans) is a Cl−-permeable… read more here.
Keywords: duct; collecting duct; channel collecting; clc ... See more keywords